Central Giant Cell Granuloma of the Mandible in an Elderly Patient: A Diagnostic Challenge

CASE REPORT
Samah O Mohager, Asim Saleem Almaaytah, Wafaey Badawy

 
For citation: Mohager SO, Almaaytah AS, Badawy W. Central Giant Cell Granuloma of the Mandible in an Elderly Patient: A Diagnostic Challenge. International Journal of Biomedicine. 2026;16(2):278-280. doi:10.21103/Article16(2)_CR4
 
Originally published June 5, 2026

Abstract: 

Background: Central giant cell granuloma (CGCG) is a rare benign osteolytic lesion of the jaws, predominantly affecting young females. Occurrence in elderly patients is uncommon and may pose diagnostic challenges due to overlap with other giant cell lesions, particularly brown tumor of hyperparathyroidism.
Case Presentation: We report a case of a 63-year-old woman with type 1 diabetes mellitus who presented with a well-circumscribed radiolucent lesion in the left anterior mandible associated with tooth mobility. Surgical excision and curettage were performed. Histopathological examination revealed features consistent with a giant cell lesion. Comprehensive biochemical evaluation excluded hyperparathyroidism, confirming the diagnosis of non-aggressive CGCG. The postoperative course was uneventful, and follow-up imaging demonstrated satisfactory bone regeneration.
Conclusion: This case highlights the rare occurrence of CGCG in an elderly patient and emphasizes the importance of correlating clinical, radiologic, histopathologic, and biochemical findings to establish an accurate diagnosis. Conservative surgical management can achieve favorable outcomes in non-aggressive lesions

Keywords: 
central giant cell granuloma • mandible • brown tumor • hyperparathyroidism
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Received February 8, 2026.
Accepted March 30, 2026.
© 2026 The Author(s). International Journal of Biomedicine is published by IMRDC.
This is an open access article under the CC BY-NC-ND 4.0 license.