International Journal of Biomedicine. 2022;12(2):299-302.
DOI: 10.21103/Article12(2)_OA18
Originally published June 5, 2022
The purpose of this study was to evaluate the anticoagulant activity of Thymus atlanticus leaves.
Methods and Results: This cross-sectional study was carried out in Khartoum state from March 2021 to June 2021. This study comprised 60 healthy volunteers (40% men and 60% women) aged 19-25 years. Activated partial thromboplastin time (APTT) and prothrombin time (PT) were evaluated in the blood plasma with different amounts of Thymus atlanticus leaves using Coatron M1 (TECO Medical Devices). Thymus atlanticus leaves considerably lengthened APTT and PT in all tested concentrations. Furthermore, only the APTT test at a concentration of 5.17 μl revealed a significant difference in the anticoagulant activity of Thymus atlanticus leaves between males and females. No correlation between age and anticoagulant activity of Thymus atlanticus leaves on PT and APTT in the study was found.
- Xu X, Liu W, Li W, Liu S. Anticoagulant activity of crude extract of Holotrichia diomphalia larvae. J Ethnopharmacol. 2016 Jan 11;177:28-34. doi: 10.1016/j.jep.2015.11.015.
- Félix-Silva J, Souza T, Camara RB, Cabral B, Silva-Júnior AA, Rebecchi IM, Zucolotto SM, Rocha HA, Fernandes-Pedrosa Mde F. In vitro anticoagulant and antioxidant activities of Jatropha gossypiifolia L. (Euphorbiaceae) leaves aiming therapeutical applications. BMC Complement Altern Med. 2014 Oct 20;14:405. doi: 10.1186/1472-6882-14-405.
- Al-Snafi AE. Medicinal plants possessed antioxidant and free radical scavenging effects (part 3) -A review. IOSR J Pharm. 2017;7(4):48–62.
- Yang X, Li Y, Li Y, Ren X, Zhang X, Hu D, Gao Y, Xing Y, Shang H. Oxidative Stress-Mediated Atherosclerosis: Mechanisms and Therapies. Front Physiol. 2017 Aug 23;8:600. doi: 10.3389/fphys.2017.00600.
- Eddouks M, Maghrani M, Lemhadri A, Ouahidi ML, Jouad H. Ethnopharmacological survey of medicinal plants used for the treatment of diabetes mellitus, hypertension and cardiac diseases in the south-east region of Morocco (Tafilalet). J Ethnopharmacol. 2002 Oct;82(2-3):97-103. doi: 10.1016/s0378-8741(02)00164-2.
- Hmidani A, Bouhlali E, Khouya T, Ramchoun M, Filali-zegzouti Y, Benlyas M, Alem C. Effect of extraction methods on antioxidant and anticoagulant activities of Thymus atlanticus aerial part. Scientific African. 2019;5 (September): e00143. doi.org/10.1016/j.sciaf.2019.e00143
- Bouhlali E, Alem C, Ennassir J, Benlyas M, Mbark AN, Zegzouti YF. Phytochemical compositions and antioxidant capacity of three date (Phoenix dactylifera L.) seeds varieties grown in the South East Morocco. Journal of the Saudi Society of Agricultural Sciences. 2017;16(4):350-357. doi: 10.1016/j.jssas.2015.11.002
- Bouhlali E, Bammou M, Sellam K, Benlyas M, Alem C, Filali-Zegzouti Y. Evaluation of antioxidant, antihemolytic and antibacterial potential of six Moroccan date fruit (Phoenix dactylifera L.) varieties. Journal of King Saud University-Science. 2016; 28(2):136-142. DOI: 10.1016/j.jksus.2016.01.002
- Athukorala Y, Jung WK, Vasanthan T, Jeon Y-J. An anticoagulative polysaccharide from an enzymatic hydrolysate of Ecklonia cava. Carbohydrate Polymers. 2006; 66(2):184-191. doi:10.1016/j.carbpol.2006.03.002
- Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 2006 Nov;3(11):e442. doi: 10.1371/journal.pmed.0030442.
- Mega JL, Simon T. Pharmacology of antithrombotic drugs: an assessment of oral antiplatelet and anticoagulant treatments. Lancet. 2015 Jul 18;386(9990):281-91. doi: 10.1016/S0140-6736(15)60243-4.
- Nardini M, Natella F, Scaccini C. Role of dietary polyphenols in platelet aggregation. A review of the supplementation studies. Platelets. 2007 May;18(3):224-43. doi: 10.1080/09537100601078083.
- Evangelista JH, De Vera MJ, Garcia RS, Joven MG, Nerosa MJA, Solidum JN. Preliminary Assessment of In vitro Anticoagulant Activity vs. Heparin 1,000 IU and Cytotoxicity of Selected Philippine Medicinal Plants. Int J Chemical Environ Eng. 2012;3(6):371-376.
- Bi Q, Han B, Feng Y, Jiang Z, Yang Y, Liu W. Antithrombotic effects of a newly purified fibrinolytic protease from Urechis unicinctus. Thromb Res. 2013 Aug;132(2):e135-44. doi: 10.1016/j.thromres.2013.07.001.
- Khouya T, Ramchoun M, Hmidani A, Amrani S, Harnafi H, Benlyas M. et al. Chemical characterization and evaluation of antioxidant, anti-inflammatory and anticoagulant activity of aqueous extract and organic fractions of thymus Zygis L. sub SP. Gracilis. International Journal of Pharmaceutical Sciences and Research. 2016; 7(4), 1396.-05. doi: 10.13040/IJPSR.0975-8232.7(4).1396-05.
Download Article
Received February 16, 2022.
Accepted April 5, 2022.
©2022 International Medical Research and Development Corporation.