Relationship between Serum Parathyroid Hormone Levels and 24-Hour Ambulatory Blood Pressure Monitoring Parameters in Hypertensive Patients

ORIGINAL ARTICLE
Chi Thang Doan, Van Minh Huynh, Cong Huy Nguyen

 
For citation: Doan CT, Huynh VM, Nguyen CH. Relationship between Serum Parathyroid Hormone Levels and 24-Hour Ambulatory Blood Pressure Monitoring Parameters in Hypertensive Patients. International Journal of Biomedicine. 2024;14(4):545-550. doi:10.21103/Article14(4)_OA1
Originally published December 5, 2024
 

Abstract: 

Background: We conducted this study to investigate and evaluate the correlation between the serum parathyroid hormone (PTH) concentrations and 24-hour ABPM parameters in hypertensive patients
Methods and Results: A cross-sectional descriptive study was conducted in the Cardiology Department of Hue Central Hospital on 74 hypertensive patients. All patients underwent 24-hour ABPM. Serum PTH was measured using a sandwich electrochemiluminescence immunoassay on a Cobas 8000. The mean values of daytime systolic blood pressure (SBP), daytime diastolic blood pressure (DBP), nighttime SBP, and nighttime DBP were  127.74±14.44 mmHg, 77.24±9.01 mmHgm, 122.86±16.57 mmHg, and 76.92±11.69 mmHg, respectively. The median value of serum PTH concentration was 68.6 pg/mL (39.83 pg/mL - 87.46 pg/mL).

All patients were divided into two groups. Group 1 included 40 AH patients with serum PTH >65 pg/mL, and Group 2 included 34 AH patients with serum PTH≤65 pg/mL. The mean values of 24-hour SBP, nighttime SBP, nighttime DBP, and nighttime mean blood pressure (MBP) in Group 1 were significantly higher than in Group 2 (P<0.05). Meanwhile, the patients of Group 1 had a statistically significantly higher rate of nocturnal blood pressure dipping and early morning blood pressure surge than the patients of Group 2 (P<0.01). We found a moderate positive correlation between serum PTH concentration and nighttime SBP (r=0.595; P<0.001), nighttime DBP (r=0.666; P<0.001), and nighttime MBP (r=0.560; P<0.001). In multivariate regression analysis, only nighttime SBP and nighttime DBP were two independent factors that significantly predicted the PTH index.
Conclusion: The serum PTH concentration shows a moderate positive correlation with nocturnal DBP, nocturnal SBP, and nocturnal MBP. Only nocturnal DBP and nocturnal SBP are independent factors significantly predicting PTH levels.
Background: We conducted this study to investigate and evaluate the correlation between the serum parathyroid hormone (PTH) concentrations and 24-hour ABPM parameters in hypertensive patients
Methods and Results: A cross-sectional descriptive study was conducted in the Cardiology Department of Hue Central Hospital on 74 hypertensive patients. All patients underwent 24-hour ABPM. Serum PTH was measured using a sandwich electrochemiluminescence immunoassay on a Cobas 8000. The mean values of daytime systolic blood pressure (SBP), daytime diastolic blood pressure (DBP), nighttime SBP, and nighttime DBP were  127.74±14.44 mmHg, 77.24±9.01 mmHgm, 122.86±16.57 mmHg, and 76.92±11.69 mmHg, respectively. The median value of serum PTH concentration was 68.6 pg/mL (39.83 pg/mL - 87.46 pg/mL).
All patients were divided into two groups. Group 1 included 40 AH patients with serum PTH >65 pg/mL, and Group 2 included 34 AH patients with serum PTH≤65 pg/mL. The mean values of 24-hour SBP, nighttime SBP, nighttime DBP, and nighttime mean blood pressure (MBP) in Group 1 were significantly higher than in Group 2 (P<0.05). Meanwhile, the patients of Group 1 had a statistically significantly higher rate of nocturnal blood pressure dipping and early morning blood pressure surge than the patients of Group 2 (P<0.01). We found a moderate positive correlation between serum PTH concentration and nighttime SBP (r=0.595; P<0.001), nighttime DBP (r=0.666; P<0.001), and nighttime MBP (r=0.560; P<0.001). In multivariate regression analysis, only nighttime SBP and nighttime DBP were two independent factors that significantly predicted the PTH index.
Conclusion: The serum PTH concentration shows a moderate positive correlation with nocturnal DBP, nocturnal SBP, and nocturnal MBP. Only nocturnal DBP and nocturnal SBP are independent factors significantly predicting PTH levels.

Keywords: 
arterial hypertension • parathyroid hormone • ambulatory blood pressure monitoring
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Received October 8, 2024.
Accepted November 16, 2024.
©2024 International Medical Research and Development Corporation.