For citation: AlAseeri AA. Unmasking the Hidden Threat: Post-COVID-19 Ischemic Stroke in a Young Adult. International Journal of Biomedicine. 2024;14(4):709-711. doi:10.21103/Article14(4)_CR1
Originally published December 5, 2024
As of February 2024, over 774 million confirmed cases of COVID-19 and more than seven million deaths have been reported globally. Severe complications from COVID-19, such as cerebrovascular events, are prevalent, with research indicating that cerebrovascular accidents (CVAs) can occur in up to 6% of COVID-19 patients. This study presents a case of ischemic stroke in a 28-year-old male with no known risk factors, occurring 14 days after a COVID-19 infection. The patient's neurological examination revealed significant weakness in the right upper and lower limbs. Magnetic resonance imaging (MRI) findings were consistent with an acute ischemic stroke. The diagnosis of ischemic stroke was based on clinical symptoms and radiological findings. Cardiovascular evaluation did not find characteristic risk factors. SARS-CoV-2 IgG antibodies tested positive, indicating previous infection. This case underscores the importance of considering COVID-19 as a potential precipitating factor for ischemic stroke, even in young individuals without other vascular risk factors.
- COVID-19. UKHSA data dashboard. Available from: https://ukhsa-dashboard.data.gov.uk/topics/COVID-19
- National Health Service. England. Available from: https://www.england.nhs.uk/statistics/statistical-work-areas/COVID-19-ho...
- ZOE health study. COVID-19 infections in the UK today. Available from: https://health-study.joinzoe.com/data
- COVID-19: Interest over time. Available from: https://trends.google.com/trends/explore?geo=GB&q=%2Fg%2F11mtd7fx1k&hl=en-GB
- Office for National Statistics. Coronavirus (COVID-19) Infection Survey, UK: 1 April 2022. Available from: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/...
- World Health Organization. COVID-19 epidemiological update – 16 February 2024. Available from: https://www.who.int/publications/m/item/COVID-19-epidemiological-update-16-february-2024
- Perry RJ, Smith CJ, Roffe C, Simister R, Narayanamoorthi S, Marigold R, Willmot M, Dixit A, Hassan A, Quinn TJ, Ankolekar S, Zhang L, Banerjee S, Ahmed U, Padmanabhan N, Ferdinand P, McGrane F, Banaras A, Marks IH, Werring DJ; SETICOS collaborators. Characteristics and outcomes of COVID-19 associated stroke: a UK multicentre case-control study. J Neurol Neurosurg Psychiatry. 2021 Mar;92(3):242-248. doi: 10.1136/jnnp-2020-324927. Epub 2020 Nov 5. PMID: 33154179.
- Merkler AE, Parikh NS, Mir S, Gupta A, Kamel H, Lin E, Lantos J, Schenck EJ, Goyal P, Bruce SS, Kahan J, Lansdale KN, LeMoss NM, Murthy SB, Stieg PE, Fink ME, Iadecola C, Segal AZ, Cusick M, Campion TR Jr, Diaz I, Zhang C, Navi BB. Risk of Ischemic Stroke in Patients With Coronavirus Disease 2019 (COVID-19) vs Patients With Influenza. JAMA Neurol. 2020 Jul 2;77(11):1–7. doi: 10.1001/jamaneurol.2020.2730. Epub ahead of print. PMID: 32614385; PMCID: PMC7333175.
- Dhamoon MS, Thaler A, Gururangan K, Kohli A, Sisniega D, Wheelwright D, Mensching C, Fifi JT, Fara MG, Jette N, Cohen E, Dave P, DiRisio AC, Goldstein J, Loebel EM, Mayman NA, Sharma A, Thomas DS, Vega Perez RD, Weingarten MR, Wen HH, Tuhrim S, Stein LK; Mount Sinai Stroke Investigators*. Acute Cerebrovascular Events With COVID-19 Infection. Stroke. 2021 Jan;52(1):48-56. doi: 10.1161/STROKEAHA.120.031668. Epub 2020 Dec 7. PMID: 33280551..
- Taylor BES, Khandelwal P, Rallo MS, Patel P, Smith L, Sun H, Nanda A, Singla A, Roychowdhury S, Cheng RC, Lee K, Gupta G, Johnson SA. Outcomes and Spectrum of Major Neurovascular Events Among COVID-19 Patients: A 3-Center Experience. Neurosurg Open. 2020 Sep;1(3):okaa008. doi: 10.1093/neuopn/okaa008. Epub 2020 Jul 17. PMID: 34632389; PMCID: PMC7454798.
- Sagris D, Papanikolaou A, Kvernland A, Korompoki E, Frontera JA, Troxel AB, Gavriatopoulou M, Milionis H, Lip GYH, Michel P, Yaghi S, Ntaios G. COVID-19 and ischemic stroke. Eur J Neurol. 2021 Nov;28(11):3826-3836. doi: 10.1111/ene.15008. Epub 2021 Jul 17. PMID: 34224187; PMCID: PMC8444875.
- Janes F, Sozio E, Gigli GL, Ripoli A, Sbrana F, Kuris F, Nesi L, Semenzin T, Bertolino G, Deana C, Bagatto D, Ciardi C, Fabris M, Merlino G, Bax F, Nilo A, Pez S, Valente M, Tascini C. Ischemic strokes in COVID-19: risk factors, obesity paradox, and distinction between trigger and causal association. Front Neurol. 2023 Aug 1;14:1222009. doi: 10.3389/fneur.2023.1222009. PMID: 37592943; PMCID: PMC10428626.
- Finsterer J, Scorza FA, Scorza CA, Fiorini AC. Ischemic stroke in 455 COVID-19 patients. Clinics (Sao Paulo). 2022 Feb 14;77:100012. doi: 10.1016/j.clinsp.2022.100012. PMID: 35240494; PMCID: PMC8841215.
- Thompson A, Morgan C, Smith P, Jones C, Ball H, Coulthard EJ, Moran E, Szewczyk-Krolikowski K, Rice CM. Cerebral venous sinus thrombosis associated with COVID-19. Pract Neurol. 2020 Oct 8:practneurol-2020-002678. doi: 10.1136/practneurol-2020-002678. Epub ahead of print. PMID: 33033161.
- Tu TM, Goh C, Tan YK, Leow AS, Pang YZ, Chien J, Shafi H, Chan BP, Hui A, Koh J, Tan BY, Umapathi NT, Yeo LL. Cerebral Venous Thrombosis in Patients with COVID-19 Infection: a Case Series and Systematic Review. J Stroke Cerebrovasc Dis. 2020 Dec;29(12):105379. doi: 10.1016/j.jstrokecerebrovasdis.2020.105379. Epub 2020 Oct 6. PMID: 33254369; PMCID: PMC7538072.
- Dakay K, Cooper J, Bloomfield J, Overby P, Mayer SA, Nuoman R, Sahni R, Gulko E, Kaur G, Santarelli J, Gandhi CD, Al-Mufti F. Cerebral Venous Sinus Thrombosis in COVID-19 Infection: A Case Series and Review of The Literature. J Stroke Cerebrovasc Dis. 2021 Jan;30(1):105434. doi: 10.1016/j.jstrokecerebrovasdis.2020.105434. Epub 2020 Nov 6. PMID: 33190109; PMCID: PMC7833244.
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Received September 28, 2024.
Accepted October 22, 2024.
©2024 International Medical Research and Development Corporation.