For citation: Rrakaqi B, Telhaj E, Elezaj N, Kaçiu Y, Xhafa B, Gjonbalaj N, Jashari A, Bajrami I, Kadolli A, Imeri B, Hamidi D, Ukaj R. Evaluation of Hounsfield Numbers and Electron Density for a CT Simulator and Their Importance for Radiotherapy Treatments. International Journal of Biomedicine. 2025;15(2):358-363. doi:10.21103/Article15(2)_OA14
Originally published June 5, 2025
Since its introduction in the early 1970s, computed tomography (CT) has significantly improved accuracy in radiotherapy planning by enhancing geometric volume definitions and dose calculation distributions. CT scans provide a distribution of attenuation values relative to water, measured in Hounsfield units (HUs), which correlate with the linear attenuation coefficient (μ). These coefficients depend on the electron density and elemental composition of the tissues.
Using fundamental physical information, such as the size, shape, and location of inhomogeneities in anatomical structures combined with HU values from the CT scan, the data is integrated into the treatment-planning system's database. This integration enables precise planning for radiotherapy treatments. To establish the HU scale for our CT simulator, our medical physics department scanned the CIRS phantom. By analyzing the phantom images, we determined the HU calibration curve for our CT-Sim system. Using this calibration, along with data from our medical linear accelerator, we created specific photon treatment beams for radiotherapy applications.
- Knöös T, Wieslander E, Cozzi L, Brink C, Fogliata A, Albers D, Nyström H, Lassen S. Comparison of dose calculation algorithms for treatment planning in external photon beam therapy for clinical situations. Phys Med Biol. 2006 Nov 21;51(22):5785-807. doi: 10.1088/0031-9155/51/22/005. Epub 2006 Oct 24. PMID: 17068365.
- Palmans H, Nafaa L, De JJ, Gillis S, Hoornaert MT, Martens C, Piessens M, Thierens H, Van der Plaetsen A, Vynckier S. Absorbed dose to water based dosimetry versus air kerma based dosimetry for high-energy photon beams: an experimental study. Phys Med Biol. 2002 Feb 7;47(3):421-40. doi: 10.1088/0031-9155/47/3/305. PMID: 11848121.
- Barret A, Dobbs J, Morris S, Roques T. Practical Radiotherapy Planning, Fourth Edition, London, England; 2009:10-85
- Khan MF. The Physics of Radiation Therapy, Fourth Edition. Minneapolis, Minnesota; 2010:5-67
- Dutreix A. et al. Monitor unit calculation for high energy photon beams, Physics for Clinical Radiotherapy, Belgium; 1997:48-132
- Almond PR, Biggs PJ, Coursey BM, Hanson WF, Huq MS, Nath R, Rogers DW. AAPM's TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams. Med Phys. 1999 Sep;26(9):1847-70. doi: 10.1118/1.598691. PMID: 10505874.
- International Atomic Energy Agency, Technical Report Series No. 398. Absorbed Dose Determination in External Beam Radiotherapy. An International Code of Practice for Dosimetry Based Standards of Absorbed Dose to Water, IAEA, Vienna; 2000:3-180
- International Commission on Radiation Units and Measurements. Dosimetry of High-Energy Photon Beams Based on Standards of Absorbed Dose to Water, ICRU Report Nr. 64, Bethesda, MD. ICRU. 2000:1-450
- Ahnesjö A. Collapsed cone convolution of radiant energy for photon dose calculation in heterogeneous media. Med Phys. 1989 Jul-Aug;16(4):577-92. doi: 10.1118/1.596360. PMID: 2770632.
- Telhaj E, Rrakaqi B, Elezaj Nj, Kaçiu Y,Imeri i Kadolli A, Comparison of IMRT techniques for head and neck cancer treatments based on two different mathematical algorithms Anisotropic analytical algorithm and convolution/superposition. International Scientific Journal. Science. Business. Society.2025;10(1):5-8
- Xhafa B, Telhaj E, Selimi F, Kaçiu Y, Elezaj N, Rrakaqi B. Utilizing the VMAT Technique for Treating Head and Neck Cancer with Fixed Collimator Jaws. International Journal of Biomedicine. 2024;14(3):474-477. doi:10.21103/ Article14(3)_OA14.
- Telhaj E, Rrakaqi B, Xhafa B, Elezaj N, Kaçiu Y. Algorithmical Applications in the XiO Treatment Plan Based on Dosimetric Measurements. International Journal of Biomedicine. 2024;15(1):162-166. doi:10.21103/Article15(1)_OA18
- Nordstrom F. Quality Assurance in Radiotherapy. London University, Malmo, 2012.
- European Society for Therapeutic Radiology and Oncology. Monitor Unit Calculation for High Energy Photon Beams, Practical Examples, Booklet No.3. Belgium, 2001.
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Received March 25, 2025.
Accepted May 26, 2025.
©2025 International Medical Research and Development Corporation.