¹Tashkent Medical Academy, Tashkent, Uzbekistan
²Bukhara State Medical Institute, Bukhara, Uzbekistan
Alanine and aspartate aminotransferase levels often increase, without any accompanying clinical signs of liver disease. This biochemical phenomenon has increasingly begun to attract the attention of specialists because of the frequency of its occurrence, which is the reason for the rising recognition of the reality of this problem. In fact, determination of the increased level of transaminases at first suggests its relation to some liver disease, despite the absence of its clinical manifestations. Frequently, this is followed by a long process of looking for various liver diseases by both the doctor and patient. In principle, this approach is justified and undisputed. However, the question that arises is whether this tactic is always acceptable! If not, what alternative is to be sought for in such cases? These and other unresolved issues were the reasons that prompted this study, to take a fresh look at this rather old problem.
- Herman EN, Maevskaya MV, Lyusina EO, Ivashkin VT. The principles of a patient with an asymptomatic increase in serum aminotransferase activity (Clinical observation). Russian Journal of Gastroenterology, Hepatology, Coloproctology 2011; 1:63-68.
- Pavlov AI, Khazanov AI. Laboratory diagnosis of alcohol intoxication in patients with alcoholic liver disease. Russian Journal of Gastroenterology, Hepatology, Coloproctology 2010; 1:44-51.
- Аnderson FH, Lecheng Z, Rock NR, Yoshida EM. An assessment of the clinical utility of serum ALT and AST in chronic hepatitis C. Hepatology Research 2000; 18: 63–71.
- Аssy N, Minuk GY. Serum aspartate but not alanine aminotransferase levels help to predict the histological features of chronic hepatitis C viral infections in adults. The American Journal of Gastroenterology 2000; 95:1545–1550.
- Cadiot G, Ink O, Boutron A, Hanny Ph, Laurent-Puig P, Buffet C. Mitochondrial aspartate amintransferase in nonalcoholic cirrhosis. Gastroenterology 1989; 97:240–241.
- Conigrave K M, Degenhardt LJ, Whitfield JB, Saunders JB, Helander A, Tabakoff B. CDT, GGT, and AST as markers of alcohol use: The WHO/ISBRA collaborative project. Alcoholism: Clinical and Experimental Research 2002; 26:332–339.
- Imperial TF, Said AT, Cummings O W, Born LJ. Need for validation of clinical decision aids: Use of the AST/ALT ratio in predicting cirrhosis in chronic hepatitis C. The American Journal of Gastroenterology 2000; 95:2328–2332.
- Giannini E, Risso D, Testa R. Transportability and reproducibility of the AST/ALT ratio in chronic hepatitis C patients. The American Journal of Gastroenterology 2001; 96: 918–919.
- Giannini E, Risso D, Botta F, Chiarbonello B, Fasoli A, Malfatti F, Romagnoli P, Testa E, Ceppa P, Testa R. Validity and clinical utility of the aspartate aminotransferase-alanine aminotransferase ratio in assessing disease severity and prognosis in patients with hepatitis C virus-related chronic liver disease. Archives of Internal Medicine 2003; 163:218–224.
- Matloff DS, Selinger MJ, Kaplan MM. Hepatic transaminase activity in alcoholic liver disease. Gastroenterology 1980; 78:1389–1392.
- Misirlioglu ED, Albayrak MA, Aliefendioglu D. Elevations of serum aminotransferase in muscular dystrophy. The Turkish Journal of Gastroenterology 2008; 19(3): 202.
- Nalpas B, Vassault A, Le Guillou A, Lesgourgues B, Ferry N, Lacour B, Berthelot P. Serum activity of mitochondrial aspartate aminotransferase: A sensitive marker of alcoholism with or without alcoholic hepatitis. Hepatology 1984; 4: 893–896.
- Park GJH, Lin BPC, Ngu MC, Jones DB, Katelaris PH. Chronic viral hepatitis and liver cirrhosis. Aspartate aminotransferase: alanine aminotransferase ratio in chronic hepatitis C infection: Is it a useful predictor of cirrhosis? Journal of Gastroenterology and Hepatology 2000; 15: 386–390.
- Pohl A, Behling C, Oliver D, Kilani M, Monson P, Hassanein T. Serum aminotransferase levels and platelet counts as predictors of degree of fibrosis in chronic hepatitis C virus infection. The American Journal of Gastroenterology 2001; 96: 3142–3146.
- Pratt DS, Kaplan MM. Evaluation of abnormal live-enzyme results in asymptomatic patients. N Engl J Med 2000; 342:1266-71.
- Reedy DW, Loo AT, Levine RA. AST/ALT ratio ≥1 is not diagnostic of cirrhosis in patients with chronic hepatitis C. Digestive Diseases and Sciences 1998; 9: 2156–2159.
- Sheth SG, Flamm SL, Gordon FD, Chopra S. AST/ALT ratio predicts cirrhosis in patients with chronic hepatitis C virus infection. The American Journal of Gastroenterology 1998; 93:44–48.
- Sorbi D, Boynton J, Lindor KD. The ratio of aspartate aminotransferase to alanine aminotransferase: Potential value in differentiating nonalcoholic steatohepatitis from alcoholic liver disease. The American Journal of Gastroenterology 1999; 94: 1018–1022.
- Williams ALB, Hoofnagle JH. Ratio of serum aspartate to alanine aminotransferase in chronic hepatitis; relationship to cirrhosis. Gastroenterology 1988; 95: 734–739.
Int J Biomed. 2011;1(4):249-252.©2012 International Medical Research and Development Corporation. All rights reserved