Advancing Thermal Cancer Therapies: The Role of Mathematical Oncology in Precision Medicine

REVIEW
Marija Radmilović-Radjenović, Branislav Radjenović

 
For citation: Radmilović-Radjenović M, Radjenović B. Advancing Thermal Cancer Therapies: The Role of Mathematical Oncology in Precision Medicine. International Journal of Biomedicine. 2025;15(3):457-460. doi:10.21103/Article15(3)_RA4
 
Originally published September 5, 2025

Abstract: 

Mathematical oncology is pivotal in advancing thermal cancer therapies, such as radiofrequency ablation, microwave ablation, and cryoablation, which provide minimally invasive alternatives for patients ineligible for surgical intervention. This review underscores the role of mathematical modeling in optimizing treatment strategies through precise planning, real-time monitoring, and adaptive adjustments. By integrating tumor characteristics, heat distribution, and treatment responses, these models may enhance the efficacy of thermal therapies. Challenges in model validation, clinical integration, and scalability are discussed, alongside future directions that emphasize the development of multi-scale, adaptive models incorporating immunological and pharmacological interactions. Ultimately, mathematical oncology bridges theoretical insights with clinical applications, significantly advancing precision medicine in thermal cancer treatment.

Keywords: 
thermal therapy • ablation • tumor • mathematical oncology
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Received July 3, 2025.
Accepted July 31, 2025.
©2025 International Medical Research and Development Corporation.