Oxidative Stress and Oral microbiota in Periodontitis (Brief-Review)

REVIEW
Marina A. Darenskaya, Ivan S. Goncharov, Natalya A. Yuzvak, Sergey I. Kolesnikov, Natalya E. Bolshedvorskaya, Lyubov I. Kolesnikova

 
For citation: Darenskaya MA, Goncharov IS, Yuzvak NA, Kolesnikov SI, Bolshedvorskaya NE, Kolesnikova LI. Oxidative Stress and Oral microbiota in Periodontitis (Brief-Review). International Journal of Biomedicine. 2025;15(4):634-638. doi:10.21103/Article15(4)_RA2
 
Originally published December 5, 2025

Abstract: 

The investigation of periodontitis pathogenesis is critically important due to its global prevalence. It has been established that periodontitis is associated with chronic periodontal inflammation, alveolar bone loss, the development of oxidative stress, and oral microbiota dysbiosis. Oxidative stress biomarkers (e.g., malondialdehyde, 8-OHdG) and genetic factors (CXCR4, SELL, ITGAL) exacerbate tissue damage and osteoclastogenesis.  The oral microbiota plays a significant role in the development and progression of periodontitis through complex interactions with host immune responses, mediated by pathogenic bacteria like Porphyromonas gingivalis and their metabolic byproducts. Emerging therapies targeting OS (e.g., resveratrol, curcumin) and microbial balance highlight the need for integrated treatment strategies.  In this context, it is particularly relevant to investigate the interplay between oxidative stress and microbial dysbiosis to develop targeted therapeutic strategies for the prevention and treatment of periodontitis and its systemic complications.

Keywords: 
periodontitis• pathogenesis • oxidative stress • inflammation • oral microbiome • systemic links
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Received April 14, 2025.
Accepted September 16, 2025.
©2025 International Medical Research and Development Corporation.