Regional Lymphatic Status in Oral Squamous Cell Carcinoma: A Brief Review

REVIEW
A. D. Dadamov, A. M. Gizatullina, Sh. N. Yakubov, R. Kh. Nabiev, Zh. E. Dusmatov

 
For citation: Dadamov AD, Gizatullina AM, Yakubov ShN, Nabiev RKh, Dusmatov ZhE. Regional Lymphatic Status in Oral Squamous Cell Carcinoma: A Brief Review. International Journal of Biomedicine. 2025;15(4):639-644. doi:10.21103/Article15(4)_RA3
 
Originally published December 5, 2025

Abstract: 

Oral squamous cell carcinoma (OSCC) is a common type of head and neck malignancy, leading to high morbidity and mortality rates. This brief review focuses on the regional lymphatic status in patients with OSCC. The lymphatic system plays a key role in the dissemination of malignant cells from the primary tumor. Tumor cell migration into the lymphatic system is a complex process involving multiple mechanisms and interactions within the tumor microenvironment. This multistep process is associated with the complex role of lymphatic endothelial cells in the tumor microenvironment, lymphangiogenesis, lymphatic invasion, and the modulation of the immune response. Despite recent advances, the precise role of the regional lymphatic system in the progression of OSCC remains unclear, highlighting the need for further in-depth study.

Keywords: 
oral cancer • lymph node • lymphangiogenesis • lymphovascular invasion • metastases
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Received October 24, 2025.
Accepted November 25, 2025.
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