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Stopping anti-obesity medications leads to significant weight regain, starting as early as eight weeks and stabilizing by six months. Despite this rebound, most patients maintain some weight loss compared to baseline a year after discontinuation.

The COVID-19 pandemic accelerated biological brain aging in older adults by an average of 5.5 months over less than three years, regardless of infection status. Social disruption, age, male sex, and socioeconomic disadvantage heightened vulnerability, while only infected individuals showed measurable declines in executive function.