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Researchers at Memorial Sloan Kettering Cancer Center (MSK) have made an important discovery about how genetic mutations in breast cancer patients can interact and drive resistance to certain drugs called CDK4/6 inhibitors. This finding, published in Nature, suggests a new strategy for predicting and preventing resistance to specific therapies based on the tumor's genetic profile.

Humans and animals share a remarkable capacity to sense when others are in distress and respond with comforting behavior. But the motivation for doing so, and why it sometimes breaks down, has been poorly understood.

Diabetic macrovascular complications are the main cause of death and disability in diabetes patients, of which vascular calcification is one of the key pathological mechanisms. Calcification in atherosclerotic plaque can cause stiffness and decreased compliance of the vascular wall, and induce atherosclerotic plaque rupture, which increases the risk of acute cardiovascular events.

A White House briefing in September 2025 that raised concerns about acetaminophen use during pregnancy and promoted the drug leucovorin as a potential autism treatment was followed by sharp changes in how doctors prescribed those medications nationwide, according to a new study.

Specialist palliative care has the potential to reduce costs by up to £8,000 per person and improve quality of life.

A new technology has been developed to suppress immune rejection, the biggest challenge in organ transplantation, without causing systemic side effects. A research team from Pohang University of Science and Technology (POSTECH) and Ewha Womans University has developed the "Immune-Shield" technology, which directly sprays immunosuppressants onto the surface of organs using mussel-derived adhesive protein.

Methionine restriction (MR) has shown significant promise in cancer therapy because it targets the unique methionine dependency of many tumors. However, despite extensive research on MR, a clear synthesis of preclinical findings and their translation into clinical settings is lacking. This review aims to address this gap by consolidating existing evidence, identifying challenges, and highlighting opportunities for advancing MR as a viable cancer treatment strategy.

Antimicrobial resistance (AMR) threatens human, animal, and environmental health globally. An international team from leading institutions, including the University of Edinburgh, London School of Hygiene and Tropical Medicine, North Carolina State University, and the International Centre for Antimicrobial Resistance Solutions, identifies fundamental gaps in current mathematical modelling approaches that prevent translation of science into policy, including data limitations, knowledge gaps about AMU-AMR relationships, and the absence of international coordination mechanisms similar to climate change efforts. They call for transdisciplinary collaboration to build integrated modelling architectures.

Researchers at the National University of Singapore (NUS) have identified a protein called tyrosine phosphatase 1B (PTP1B) as a potential "switch" that can modulate a type of cancer cell death known as immunogenic cell death (ICD).

The world's first lab-based tick feeding system for bush ticks, developed by researchers at the University of Melbourne, has transformed the study of ticks and how they transmit disease. The novel, host-free technology reduces the need for animal experiments in tick studies, facilitating more ethical, reproducible research.

In time for Colorectal Cancer Awareness Month in March, the Alliance for Clinical Trials in Oncology has launched a new clinical study aimed at helping improve how patients with colorectal cancer share information about the genetic risks to their family members.

During the COVID-19 pandemic, mental health specialists started using telemedicine much more frequently.

Only 1 in 6 participants maintain their daily activities without change during menstruation, according to a study on menstrual health conducted in Spain and led by the INGENIO Institute (UPV-CSIC).

Findings from a study led by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) support the potential of new therapies that could improve clinical outcomes for patients with squamous and adenocarcinoma non-small cell lung cancers (NSCLC) that don't respond to immunotherapy.

Cells in our immune system are best known for providing security against external invaders such as bacteria and viruses. These immune cells also guard against internal threats, including cancerous tumors.

Improving the gap between your biological age and your chronological age is associated with a lower risk of stroke and improvements in signs of damage in the brain, according to a preliminary study released March 5, 2026, that will be presented at the American Academy of Neurology's 78th Annual Meeting taking place April 18-22, 2026, in Chicago and online.

Mayo Clinic researchers have identified a drug-and-supplement combination therapy that is capable of reducing the harmful effects of senescent cells – also known as "zombie cells" – in diabetic kidney disease.

Researchers analyzed clinical data from 141 treatment-seeking patients with compulsive buying-shopping disorder to determine whether women and men differ in symptom severity, psychiatric comorbidities, and shopping behaviors. The study found that men and women show similar clinical severity and treatment engagement, but differ mainly in the types of products they compulsively purchase.

A prospective analysis of 2,077 children in the Canadian CHILD Cohort Study found that higher intake of ultra-processed foods at age three was associated with slightly higher behavioral and emotional symptom scores by age five. Modeling showed that replacing 10% of calories from ultra-processed foods with minimally processed foods was associated with modestly lower symptom scores.

Scientists developed Evo 2, a large biological foundation model trained on about 9 trillion DNA base pairs that can analyse genomic sequences across bacteria, plants, and humans. The model predicts functional effects of genetic variants and can generate genome-scale DNA sequences, enabling new approaches to studying and designing biological systems.