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For millions living with nerve pain, even a light touch can feel unbearable. Scientists have long suspected that damaged nerve cells falter because their energy factories known as mitochondria don't function properly.

A preclinical study uncovered a new gene therapy that targets pain centers in the brain while eliminating the risk of addiction from narcotics treatments, a breakthrough which could provide hope for the more than 50 million Americans living with chronic pain.

Fungal infections kill millions of people each year, and modern medicine is struggling to keep up. But researchers at McMaster University have identified a molecule that may help turn the tide — butyrolactol A, a chemical compound that targets a deadly, disease-causing fungi called Cryptococcus neoformans.

When a patient's heart stops in a hospital, healthcare professionals need to act quickly.

The parasite that may already live in your brain can infect the very immune cells trying to destroy it, but new UVA Health research reveals how our bodies keep it under control.

Researchers at Case Western Reserve University have developed a treatment for advanced prostate cancer that could eliminate a side effect so debilitating that patients often refuse the life-saving therapy.

Researchers have developed a new computational approach that uncovers possible drugs for specific cellular targets for treating glioblastoma, a lethal brain tumor.

For the first time, an international research team led by Nanyang Technological University, Singapore (NTU Singapore) has recorded a tiny mechanical "twitch" in living human and rodent eyes at the exact moment a rod photoreceptor detects light.

An international research team has uncovered compelling evidence that gut-microbe-derived molecules may play an important role in shaping the developing immune system during early childhood.

Triple-negative breast cancer (TNBC) is among the most aggressive types of breast cancer, lacking estrogen, progesterone, and HER2 receptors and thus relying primarily on cytotoxic chemotherapy.

The National Institutes of Health has awarded the Icahn School of Medicine at Mount Sinai an $8.5 million renewal grant to continue groundbreaking work aimed at understanding and improving long-term outcomes for children with congenital heart disease-the most common type of birth defect in the United States.

Higher consumption of food preservatives, widely used in industrially processed foods and beverages to extend their shelf life, has been linked to an increased risk of type 2 diabetes.

Light intensity activities, like walking or household chores, were linked to a lower risk of death for people with cardiovascular-kidney-metabolic (CKM) syndrome, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

A small set of common blood biomarkers predicts which older adults will develop specific combinations of chronic diseases - and how quickly, a new study from Karolinska Institutet published in Nature Medicine reports.

Metabolic diseases have reached epidemic proportions in our society, driven by a sedentary lifestyle coupled with circadian misalignment - a desynchrony between our intrinsic biological clocks and environmental signals.

Researchers at Karolinska Institutet have discovered that the nervous system's own immune cells help protect the spinal cord from age-related damage.

This perspective argues that Parkinson’s disease may involve functional iron deficiency, where bioavailable iron is limited despite normal or elevated total iron in the brain. The authors propose that iron sequestration, not iron toxicity alone, may impair dopamine synthesis and neuronal survival.

This comprehensive review synthesizes a decade of human and animal research to explain how the gut and brain communicate through hormonal, neural, immune, and microbial pathways. It highlights how disruptions in these pathways contribute to gastrointestinal, metabolic, and neurological disorders, and how modern therapies are beginning to exploit gut–brain signaling for clinical benefit.

This review synthesizes clinical, genetic, and mechanistic evidence showing that suPAR and related uPAR fragments are strongly associated with kidney, cardiovascular, and metabolic disease risk. It highlights suPAR as a stable biomarker of innate immune activation with potential pathogenic roles, while underscoring major gaps in assay standardization and therapeutic validation.

Australian researchers have uncovered how a particular strain of a diarrhea-causing parasite managed to infect more animal species, offering new insights into how parasitic infections emerge and spread to people.