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Pim1 identified as promising therapeutic target for inflammatory arthritis treatment
The research team led by Professor Zhongyu Xie from Sun Yat-sen University revealed a new mechanism by which Pim1 regulated Th17 cell differentiation through mitochondrial metabolism.
Brain functional differences reflect anatomy, lifestyle, and environmental influences
As neuroscience strives for generalizability and equity, understanding human brain diversity across populations is crucial.
Gene-based therapies could transform future pancreatitis treatment
Pancreatitis is a complex inflammatory disease driven by both genetic and environmental factors. It poses substantial clinical challenges due to a lack of disease-modifying therapies.
Study identifies major causes of fatigue among disaster responders
Real time data collected during the 2024 Noto Peninsula earthquake response show that unclear tasks and command structures, and lack of meal- and rest breaks increased self-reported fatigue among disaster responders.
Internal mutations and microbes may drive a distinct subtype of oral cancer
A new study reveals that many oral cancers are no longer driven by traditional risk factors like smoking or Human papillomavirus infection.
University of Ottawa study links heart attacks with brain damage
A new study led by a team from the University of Ottawa takes a major step forward in understanding how a heart attack can dramatically reshape brain function and trigger neurological effects, from depression and anxiety to different types of cognitive decline.
Tulane study explains why gut damage persists despite HIV treatment
For many people living with HIV, today's treatments can suppress the virus and dramatically improve health. But even when HIV is controlled, damage to the gut caused by the disease can persist, fueling chronic inflammation linked to serious health problems.
Mitochondrial checkpoint enables dendritic cells to activate T lymphocytes against viruses, tumors
A study led by researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has identified a mitochondrial "checkpoint" that enables dendritic cells to efficiently activate T lymphocytes against viruses and tumors.
Combination therapy improves response rates for chronic hepatitis B patients
The optimal management strategy for adults with immune-tolerant (IT) chronic hepatitis B infection remains undefined. This study aimed to investigate the efficacy and predictive factors of a pegylated interferon (Peg-IFN)-based treatment strategy in IT patients with chronic HBV infection.
New biomarker predicts therapy response for hard-to-treat childhood cancers
A study by researchers at the University of Birmingham has identified a new biomarker for response to a specific cancer therapy, treating children with Ewing Sarcoma and other tumor types.
Scientists map genetic variants behind prostate cancer therapy failure
Recently, the research group led by Dr. Dechao Feng, Lecturer at University College London (UCL) and Distinguished Research Fellow at Zhejiang Provincial People's Hospital, published a review entitled "Intratumoral Androgens and Genetic Variants Driving Therapy Resistance in Prostate Cancer".
Harvard researchers outline roadmap to solve orphan receptor challenge
A new review highlights how synthetic biology, AI, and spatial omics could transform ligand-receptor discovery from one-by-one searches into network-level mapping.
Targeting lipid enzymes triggers starvation states in aggressive tumor cells
While many American adults are trying to reduce cholesterol levels, certain cancerous tumors have a relentless appetite for the metabolite.
Targeting a key protein reduces injury in steatotic liver transplantation
Steatotic donor livers are highly susceptible to post-transplant dysfunction; however, the underlying mechanisms remain incompletely understood.
Scientists urge advocacy to protect vital global vaccine research
Scientists and physicians should advocate to protect the vaccine research infrastructure that has saved an estimated 154 million lives over the past 50 years, according to a new commentary by researchers at Weill Cornell Medicine and the University of Washington.
Brain scans find no evidence of widespread inflammation in long COVID
A new brain imaging study has found no evidence of widespread brain inflammation in patients suffering from prolonged symptoms after COVID-19 infection. Instead, the most severe long COVID symptoms were associated with increased brain activity in regions involved in mood and emotion.
NIH researchers discover how weight-loss drugs alter brain cells
A team of researchers at the National Institutes of Health (NIH) have unveiled new details about the events GLP-1 receptor agonists trigger within neurons, which have been largely unexplored until now.
Boston Children's scientists create new booster-free mRNA vaccine strategy
In a new study published in Nature Immunology, researchers at Boston Children's Hospital demonstrated that pairing the original COVID-19 mRNA vaccine with an immune system enhancer, known as an adjuvant, extended the duration of the vaccine's protection in mice from a few months up to two years.
New psychological scales measure personal attitudes toward cosmetic procedures
As non-surgical cosmetic procedures grow in popularity, accessibility and affordability, new Griffith University research has created two new measures to assess people's attitudes and motivations towards cosmetic procedures.
Lab-grown brain models reveal how epilepsy drug alters fetal development
It is known that the antiepileptic drug valproate increases the risk of developmental disorders in unborn children.




