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The maternal microbiome and immune system have both independent and synergistic effects on fetal brain health - changes in the mother's immune system have been linked to an increased risk of neurodevelopmental disorders in children.

A comprehensive mini-review published today after peer review in Brain Medicine by Dr. Tao Ma and colleagues at Wake Forest University School of Medicine synthesizes emerging evidence that two isoforms of a critical cellular energy sensor play distinct, and sometimes opposing, roles in Alzheimer's disease.

Neighborhood-level disadvantages are linked to reduced lower limb strength and mobility in older adults, emphasizing the need for targeted interventions.

A research team from the Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine at the University of Hong Kong (HKUMed) has uncovered a key biological mechanism that explains how exercise maintain strong bones, paving the way for novel treatments for osteoporosis and bone loss in people who are unable to engage.

The study shows that this drug pair works far better together than either agent alone, offering a realistic and potentially fast path toward a new antifibrotic therapy.

In a new study published in Liver Research, a team of researchers in China discovered that nicotinic acid-a common form of vitamin B3-can dramatically reduce liver damage caused by ischemia-reperfusion injury (IRI), a major complication in liver surgery and transplantation.

Every year, millions of infants and children undergo surgery under general anesthesia in the world. Sevoflurane is a commonly used pediatric anesthetic. Its exposure during brain development has been shown to inhibit neurogenesis and cause cognitive dysfunction in animal models.

A systematic review and meta-analysis of 15 studies found that ketogenic diets were associated with short-term reductions in body weight, waist circumference, insulin resistance, and some reproductive hormones in women with polycystic ovary syndrome, primarily among those with overweight or obesity. However, substantial heterogeneity, low certainty of evidence, limited safety reporting, and short follow-up periods mean the clinical effectiveness and long-term sustainability of ketogenic diets in PCOS remain uncertain.

Scientists at the Princeton University Branch of the Ludwig Institute for Cancer Research have identified novel mechanisms by which a metabolic derivative of vitamin A-all-trans retinoic acid-compromises both the body's normal anti-cancer immune response and, in a different context, the efficacy of a promising type of cancer vaccine.

A new peer-reviewed paper published in The Gerontologist provides the most comprehensive scientific response to date addressing recent critiques of the so-called "blue zones," regions of the world known for unusually high concentrations of people living long, healthy lives.

Public health researchers at Columbia University Mailman School of Public Health used computer modeling to reconstruct how the 2009 H1N1 flu pandemic and the 2020 COVID-19 pandemic unfolded in the U.S.

When some women orgasm, they experience unusual physical and emotional responses such as laughing, crying, headaches, tingling, foot pain, nosebleeds and more.

A study by researchers at Mass General Brigham highlights the opportunity for orthopedic surgeons to play a critical role in identifying patients who have experienced intimate partner violence (IPV).

New research led by Mass General Brigham investigators suggests that long COVID is more prevalent in school-aged children and adolescents who experience economic instability and adverse social conditions.

Researchers at Northwestern University and the University of Bern in Switzerland have conducted the first cross-temporal, multinational study to compare views of gender using data collected 30 years apart.

Scientists at St. Jude Children's Research Hospital have revealed previously unappreciated roles for the retrotransposon LINE-1 in shaping the cancer genome structure and regulation.

A groundbreaking international study has demonstrated that Alzheimer's disease biomarkers can be accurately detected using simple finger-prick blood samples that can be collected at home and mailed to laboratories without refrigeration or prior processing.

This study shows that SARS-CoV-2 infection and vaccination generate strong, highly specific spike-binding immune responses with only modest effects on immunity to endemic common cold coronaviruses. Pre-existing coronavirus immunity patterns remain largely intact, indicating that SARS-CoV-2 has integrated into the human viral landscape without broadly reshaping cross-reactive protection.

A groundbreaking new study reveals that changes to the gut microbiome can change the way the brain works.

Flu infections are rising sharply across the United States, contributing to at least​ 81,000 hospitalizations and ​3,100 deaths so far this season, according to the U. S. Centers for Disease Control and Prevention.​