Feed aggregator

A team led by LMU physician Daniel Kotlarz has identified a previously unknown genetic cause of Crohn's disease.

Sjögren disease, an autoimmune disease characterized by dry mouth and dry eyes, may reduce patients’ quality of life.

CADASIL, an inherited disease caused by mutations in the NOTCH3 gene, damages the brain’s small blood vessels, leading to strokes, cognitive decline, and early dementia.

A genetic difference carried by nearly one in three people may increase the risk of severe COVID-19 and lung fibrosis by disrupting the function of a previously unknown protein, according to a new study.

An early view of the immune response to bacteria in the lungs provides clues as to why some people keep TB in check, while others develop disease, suggesting new ways to intervene earlier and stop TB.

Research indicates that long-term wholegrain intake per Nordic guidelines is associated with reduced breast cancer risk, emphasizing food type differences.

The link between biological aging and early-onset cancer risk offers crucial insights into generational health trends and potential preventive measures.

FairJourney Bio (“FJBio”), a global antibody discovery expert, has entered a partnership with AbTherx, Inc. to bring transgenic mouse-based antibody discovery in-house. The agreement gives the Company access to AbTherx’s Atlas™ Full Human Diversity (FHD) and Common Light Chain (cLC) mouse technologies, completing a discovery route that partners can now run end to end entirely within FJBio’s integrated workflow.

A scoping review of 140 empirical studies found that human-AI collaboration in healthcare reports the most consistent benefits in diagnostic interpretation, especially when AI supports bounded tasks and clinicians retain final responsibility. Evidence remains fragmented across triage, treatment planning, and documentation, with few studies measuring patient outcomes, system impact, trust calibration, or governance in real-world settings.

A systematic review and meta-analysis of 11 randomized controlled trials found that exercise during the post-weight-loss maintenance phase reduced weight regain by an average of 2.81 kg compared with control groups. Evidence for fat-mass reduction remained inconclusive, highlighting the need for longer, standardized trials with better adherence and body-composition monitoring.

A Korean target trial emulation found that starting antidiabetic medication within 12 months of newly crossing type 2 diabetes diagnostic thresholds was associated with lower five-year all-cause mortality. MACE risk was numerically lower with earlier treatment, but the reductions in cardiovascular events were not statistically significant, underscoring the need for larger studies.

A 20-year prospective cohort study of 143,715 US healthcare professionals found that long-term resistance training was associated with a substantially lower risk of type 2 diabetes. The lowest risk was seen among participants who combined regular resistance training with adequate aerobic activity and limited TV viewing.

Random-pattern skin flaps are widely used to repair defects caused by trauma, burns, tumor removal, and other injuries because they can be designed without depending on a single named blood vessel.

Colorectal cancer is generally considered a disease of older adults. However, a new analysis of German cancer registries shows that the number of new colorectal cancer cases among younger adults has risen slightly over the past two decades.

After nearly four decades of research, Mayo Clinic scientists have revealed the molecular structures of protein kinase C beta (PKCβ), a key protein linked to cancer and neurological diseases.

Han-Chow Koh, PhD, and Frank A.J.L. Scheer, PhD, of the Medical Chronobiology Program at the Division of Sleep and Circadian Medicine in the Mass General Brigham Department of Medicine, are the co-lead and senior author, respectively, of a paper published in Metabolism, "Constant-routine protocol reveals an endogenous circadian rhythm in diet-induced thermogenesis with a peak in the biological morning."

Researchers have identified a critical biological difference in how glioblastoma develops in male and female laboratory models, pinpointing an immune pathway that fuels tumor growth only in females.

A new gene therapy has been used to successfully treat a deadly childhood liver disease using mice that model this disease by researchers at UCL and Great Ormond Street Hospital.

First-time mothers whose children go through family court care proceedings in England are 21 times more likely to die within 10 years of having their baby compared with other mothers, a new study by UCL researchers finds.

Researchers at Oregon State University have potentially found a new way to treat the most aggressive form of brain cancer, glioblastoma, whose two-year survival rate is less than 30%.