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UCLA Health researchers discover four pathways leading to Alzheimer’s disease
UCLA Health researchers have identified four distinct pathways that lead to Alzheimer's disease by analyzing electronic health records, offering new insights into how the condition develops over time rather than from isolated risk factors.
EQT to acquire Europa Biosite
We are pleased to announce that EQT Healthcare Growth (EQT) has agreed to acquire a majority stake in Europa Biosite from Adelis Equity.
Circadian misalignment in the blind may impact daily brain functions
This study investigates how blindness affects sleep, dreams, and spatial awareness, revealing links between circadian rhythms and cognitive performance.
ADA2 regulates inflammation through lysosomal and extracellular mechanisms
Adenosine deaminase 2 (ADA2) plays a critical role in immune regulation, particularly in monocyte differentiation and activation.
Multicenter study supports cautious use of low-dose HCQ in severe COVID-19 cases
This multicenter study investigates the association between hydroxychloroquine (HCQ) dosage and COVID-19 mortality among hospitalized patients in China, aiming to clarify conflicting evidence from prior research.
Preeclampsia in pregnancy reduces risk of some cancers but raises endometrial cancer odds
Women with preeclampsia in their first pregnancy had a lower risk of developing breast, cervical, and lung cancer later in life, but a higher risk of endometrial cancer. The large Nordic cohort study also found that siblings of women with PE had a modestly reduced risk of cancer, particularly lung cancer.
Study provides a molecular snapshot of Tanshi constitution's immunological landscape
The study aims to uncover the immunological basis of Tanshi (phlegm-dampness) constitution—a subhealth type in traditional Chinese medicine (TCM)—using single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs).
Eating habits directly influence vaginal microbiome, research finds
A cross-sectional study of young Italian women found that higher intake of animal protein and alcohol is associated with vaginal microbiota dysbiosis, while linolenic acid (a plant-based omega-3) and dietary fiber support beneficial Lactobacillus communities.
Amino acid metabolism in breast cancer as a driver of disease and therapeutic target
The review introduces the molecular subtypes of breast cancer and outlines how altered amino acid metabolism supports tumor growth.
Early exposure to plastics raises young children’s asthma risk
A large international study found that early-life exposure to phthalates, common chemicals in plastics, is modestly associated with increased risks of asthma, wheeze, and rhinitis in children under five. No consistent associations were found for bisphenols, and effects were generally small.
Vaping versus smoking’s impact on male fertility
A new study found that male E-cigarette users undergoing IVF had higher sperm motility and lower miscarriage rates compared to conventional smokers. However, E-cigarettes were not shown to be safe and further research is needed before recommending them for fertility.
Planned C-sections linked to increased risk of developing childhood leukemia
Children born by planned C-section have an increased risk of developing acute lymphoblastic leukemia (ALL) later in life.
Study reveals hidden cause of treatment failure in acute promyelocytic leukemia
Researchers at Zhejiang University School of Medicine have identified a single point mutation in the normal PML gene that can block the effect of arsenic trioxide, a frontline drug for acute promyelocytic leukemia.
Physician associates found effective under supervision but pose risks in unsupervised care
Physician associates provide safe and effective care when they work under the direct supervision of doctors and care for patients who have already been diagnosed, or when they undertake procedures for which they have been highly trained, finds a rapid review published in The BMJ today.
XPR1 silencing enhances immune response and reduces ovarian tumor growth
A recent study published in Genes & Diseases reveals a novel role of XPR1 in promoting ovarian cancer growth by regulating autophagy and MHC-I expression.
EMP1 identified as key driver of tumor progression in resectable pancreatic cancer
The latest research published in Genes & Diseases unveils groundbreaking insights into the role of the aging process and the associated factor EMP1 in the progression of resectable pancreatic cancer (PC).
Chemist awarded NSF grant to study DNA nanoparticles for gene therapy
Case Western Reserve University chemist Divita Mathur was awarded a National Science Foundation (NSF) Faculty Early Career Development Program (CAREER) grant for her research in synthetic DNA nanoparticles, which have potential applications in gene therapy.
Herbal extract from Caryota maxima extends lifespan through lipid metabolism
Announcing a new publication for Acta Materia Medica journal. Geroprotectors that delay aging have substantial potential for preventing and mitigating age-related diseases.
Flawed coronavirus model prompts urgent reassessment for drug developers
The COVID pandemic illustrated how urgently we need antiviral medications capable of treating coronavirus infections.
Rare kidney cancer evades immune system in unique ways
Cancer fighting T-cells, the immune system's primary enforcers, are scarce in the rare kidney cancer called chromophobe renal cell carcinoma (ChRCC) and those that are present are indifferent to the tumor threat and traditional immune therapies, revealing the need for new targets and treatments.