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Single-cell sequencing reveals why some CAR-T therapies succeed while others fail
Single-cell RNA sequencing is giving researchers a clearer view of why some CAR-T cells persist, expand, kill tumors effectively, or become exhausted. The review synthesizes 44 clinical scRNA-seq studies involving 500 patients and highlights how exhaustion, memory, cytotoxicity, clonal diversity, and metabolism may shape CAR-T responses.
New brain stimulation technique improves social communication in children with autism
A new non-invasive brain stimulation technique known as accelerated continuous theta burst stimulation (a-cTBS) improves social communication at one month follow up and has a favorable safety profile in children with autism, finds a trial from China published by The BMJ today.
New imaging agent shows promise for non-invasive endometriosis diagnosis
The Nuffield Department of Women's & Reproductive Health at the University of Oxford, together with Serac Healthcare Limited announces the publication of Phase 2 data in The Lancet Obstetrics and Gynaecology.
Study finds no psychiatric risk from prenatal sedatives
A large South Korean study published by The BMJ today finds no increased risk of psychiatric or neurodevelopmental disorders, such as ADHD and autism, in children whose mothers used sedative drugs (benzodiazepines or Z-hypnotics) during pregnancy.
Survey reveals silica dust risks for Australia’s tunnel workers
The responses to a national survey published today have revealed tunnel construction workers across Australia say they face significant exposure to silica dust, a hazardous dust that can cause incurable diseases like silicosis and lung cancer.
Maternal weight before pregnancy may shape toddlers’ development
A nationwide Korean cohort study of 258,367 mother-child pairs found that maternal pre-pregnancy BMI was associated with developmental delay risk in children aged 18 to 36 months. Children of underweight mothers showed modest early risks that later attenuated, while obesity-related risks persisted across developmental domains.
Brief walking breaks help the body control sugar after carb-rich meals
Brief brisk walking breaks during prolonged sitting improved post-meal interstitial glucose responses in healthy adults after carbohydrate-rich meals, with the strongest effects seen in women. Gluteal fat showed a more stable glucose pattern than abdominal fat, suggesting it may help buffer carbohydrate-related glucose rises through depot-specific uptake and lipid-synthesis pathways.
AHA calls for lifelong brain health strategy to prevent cognitive decline
The AHA scientific statement calls for a life-course approach to brain health that integrates cognitive, emotional, behavioral, vascular, environmental, inflammatory, sleep, microbiome, and social factors.
It highlights how early-life exposures, mental health, pollution, chronic inflammation, poor sleep, gut dysbiosis, and socioeconomic adversity may shape brain resilience and later-life cognitive decline.
Survey shows women are confused about when to start mammograms
A new national survey reveals many women are unsure about when to start mammogram screening for breast cancer and believe they should start later than doctors recommend.
Researchers use light-activated nanozymes to treat aggressive brain tumors
Brain tumors cannot always be successfully treated with conventional therapies. A team from Empa and the hospital network HOCH Health Ostschweiz is therefore developing nanozymes that can attack cancer cells directly in the brain during tumor surgery.
Cells filter physical forces based on duration to detect disease
Scientists have discovered how cells decide when to respond to physical forces, potentially opening new avenues for tackling diseases such as cancer and fibrosis.
Academic burnout pushes Chinese adolescents toward excessive online gaming habits
Chinese researchers report that academic burnout can push adolescents towards excessive online gaming. Using a large-scale cross-sectional survey, the researchers assessed the associations among academic burnout, internet gaming, depressive symptoms, and attentional bias.
Multiple myeloma mortality rates decline with advances in targeted therapies
A new research paper was published in Volume 17 of Oncotarget on April 28, 2026, titled "Targeted therapeutics and U.S. population-level mortality trends in multiple myeloma: A SEER-based analysis from 1975 to 2023."
Extreme weather and airborne dust linked to rising Valley fever cases in El Paso
A new study by researchers at The University of Texas at El Paso has identified a significant rise in Valley fever cases in El Paso over the past decade and found strong connections between the disease and extreme weather, wind and airborne dust.
New genetic risk test estimates inherited risk for cardiovascular conditions
Researchers at Mass General Brigham Heart and Vascular Institute and collaborators have developed and validated a new genetic risk test that can estimate a person's inherited risk for eight common cardiovascular conditions, offering a more comprehensive approach to prevention.
New hybrid molecule uses Trojan horse approach to treat obesity
A team led by metabolism researcher Prof Timo D. Müller at Helmholtz Munich has developed a new approach for treating obesity and type 2 diabetes: a hybrid molecule uses the well-known GLP-1/GIP signalling pathway as a "door opener" and delivers an additional metabolic modulator specifically into the target cells.
Maternal antibodies provide lifelong protection against adult gum disease
Mothers provide a hidden immune legacy that protects their children's teeth long after weaning is over. A new study reveals how maternal antibodies act as early life architects, programming the mouth to resist aggressive bacteria and prevent the bone loss associated with adult gum disease.
Oxidative stress in aging brain inhibits essential enzymes
Researchers at the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena found that oxidative stress in the aging brain inhibits the activity of deubiquitylases.
Phone-based education significantly improves inhaler technique for COPD patients
Guiding people on how to correctly use inhaled medications via a phone-based program can help improve technique, according to a new study in the March 2026 issue of Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation, a peer-reviewed, open access journal.
Eating creates temporary metabolic state that boosts T cell function
Diets and healthy eating habits hold promise for preventing and treating diseases, but far less is known about acute effects to the immune system shortly after a meal.




