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Ionophore use in farming drives global spread of antibiotic resistance genes, study finds
Researchers identified the widespread presence of the ionophore resistance genes narA and narB in over 2,400 bacterial isolates across 51 countries. These genes are often genetically linked to resistance against critically important human antibiotics, raising concerns over agricultural practices and global antimicrobial resistance.
Coffee’s hidden compounds could help fight type 2 diabetes
A comprehensive review of nearly 150 studies reveals that coffee polyphenols may help regulate blood sugar and reduce inflammation linked to type 2 diabetes. However, most evidence comes from preclinical research, and robust clinical trials are needed to confirm benefits.
Just 150 minutes of exercise a week could reverse prediabetes
Engaging in more than 150 minutes of physical activity per week quadrupled the odds of reversing prediabetes to normal glucose levels in Colombian adults. Higher BMI and HbA1c remained strong barriers to reversal, highlighting the power of lifestyle interventions.
Are sweeteners really making our children’s diets healthier?
Higher consumption of low-calorie sweetened (LCS) products among UK children was not consistently linked to reduced free sugar intake, and may reflect less healthy overall dietary patterns. Over 11 years, improvements in dietary quality were slowest among those consuming the most LCS products.
How 50,000 years of ancestry shaped India’s unique disease patterns
Scientists sequenced the genomes of 2,762 individuals across India, revealing the country’s unique ancestral makeup and a wealth of previously undocumented disease-related gene variants. The study highlights how ancient migrations, founder effects, and endogamy have shaped both diversity and disease risk in India.
Risk factors associated with emergency presentations following malignant skin cancer
Emergency department (ED) presentations are associated with higher cancer mortality. This study aimed to investigate the prevalence, frequency, and risk factors in Australian patients diagnosed with malignant skin cancers.
Early therapy for preschool depression shows long lasting benefits
Depression affects 1%-2% of children younger than 13 in the U.S. and can arise as early as age 3, but a specialized therapeutic intervention can help preschool-aged children find relief from this condition - with benefits lasting at least four years, according to a new study led by researchers at Washington University School of Medicine in St. Louis.
Targeting mitochondrial dynamics to combat breast cancer metastasis
Breast cancer, particularly triple-negative breast cancer (TNBC), remains a leading cause of cancer-related mortality due to its aggressive nature and limited therapeutic targets.
New study supports non-surgical approach for select cases of acute subdural hematoma
Acute subdural hematoma (ASDH) is a common brain lesion resulting from traumatic brain injuries and is associated with high mortality and morbidity.
Limiting carcinogen exposure could mitigate liver cancer risk for people with HBV infection
Hepatitis B virus (HBV) infection is known to be associated with the risk of hepatocellular carcinoma (HCC), but how and why they are connected remains unknown.
Newly discovered target may re-energize exhausted immune cells in the fight against cancer
Van Andel Institute scientists and collaborators have discovered a potential treatment target that may re-energize dysfunctional or "exhausted" immune cells in their fight against cancer.
PIEZO2 ion channel plays critical role in the formation of coronary vessels and the heart
The ion channel PIEZO2 doesn't just convey touch stimuli. It also plays a key role in the development of coronary vessels, a team led by Annette Hammes from the Max Delbrück Center reports in "Nature Cardiovascular Research."
FAM111B identified as a key driver of glioma progression and therapeutic target
Gliomas are among the deadliest brain tumors, with limited treatment options and poor survival rates. Scientists from China identified FAM111B, a DNA-repair-associated protein, as a key driver of glioma progression.
New enzyme can be "turned off" to restore cholesterol balance and reduce inflammation
Scientists at The University of Texas at Arlington have identified a new enzyme that can be "turned off" to help the body maintain healthy cholesterol levels-a significant development that could lead to new treatments for diseases that affect millions of Americans.
Investigating the role of ultra-processed foods in the inheritance of autism and ADHD
In a recent publication released by PubMed, American scientist Dr. Renee Dufault at the Food Ingredient and Health Research Institute, provides a peer-reviewed protocol for determining the role ultra-processed foods play in prenatal heavy metal exposures and changes in the expression of the zinc dependent MT-1 (metallothionein) gene that impact child neurodevelopment.
Exploring neural responses to mental exhaustion in healthy adults
In experiments with healthy volunteers undergoing functional MRI imaging, scientists have found increased activity in two areas of the brain that work together to react to, and possibly regulate, the brain when it's "feeling" tired and either quits or continues exerting mental effort.
New insights into exercise physiology through enduromics and resistomics
Exercise has been recognized as an extremely effective tool to improve human health— it can have a preventative and even therapeutic effect on non-communicable diseases such as diabetes and cardiovascular diseases.
Vegan diet lowers dietary acid load and promotes weight loss
Compared with a Mediterranean diet, dietary acid load decreased significantly on a low-fat vegan diet and was associated with weight loss, according to a randomized cross-over trial conducted by the Physicians Committee for Responsible Medicine and published in Frontiers in Nutrition.
Babies as young as eight months show flexible learning abilities
Babies as young as eight months old can adapt their learning style to changing situations, according to research by Francesco Poli of the Donders Institute at Radboud University.
Spaceflight research sheds light on age-related muscle decline
Sarcopenia, which is a progressive and extensive decline in muscle mass and strength, is common with aging and estimated to affect up to 50% of people aged 80 and older.