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DNA-guided CRISPR system targets RNA and expands Cas12 beyond gene editing
Researchers developed ΨDNA, a DNA-based CRISPR guide that allows Cas12 enzymes to target RNA with high specificity while retaining compatibility with DNA-editing workflows. The platform detected HCV RNA in clinical samples and enabled programmable RNA knockdown, multiplex targeting, and RNA modification in human cells.
New therapies could help type 1 diabetes care move beyond insulin alone
Disease-modifying therapies for type 1 diabetes are beginning to move care beyond insulin replacement by targeting immune dysregulation, beta-cell stress, and preservation of endogenous beta-cell function. Teplizumab marks a major clinical milestone, but the review emphasizes that durable metabolic remission will likely require earlier screening, better patient selection, and sequential or combination therapies.
Discovery of memory switch in the brain opens new avenues for dementia therapies
"Why do patients with dementia or cognitive decline remain stuck in past memories?" KAIST researchers have identified, for the first time in the world, the existence of a "neural switch" in the brain that selectively retrieves the most recent memories.
Sleep complaints highlight Alzheimer's risk in genetically predisposed women
Sleep complaints may be an important Alzheimer's disease risk factor in older women with a higher genetic predisposition to the disease, according to a new study from researchers at the University of California San Diego.
Integrated care needed for lifelong Polyendocrine Ovarian Syndrome management
Polycystic Ovary Syndrome, which has just been renamed Polyendocrine Ovarian Syndrome (PMOS), is the most common hormonal and metabolic disorder affecting women of reproductive age, impacting up to 13% of this population and contributing to nearly 40% of infertility cases worldwide.
Exhausted brain immune cells drive aggressive multiple system atrophy
A rare and fatal brain disorder with no available treatment or cure. One that attacks the nervous system, balance, and the ability to move.
Gut microbiome metabolite butyrate relieves chronic jaw joint pain
Temporomandibular joint (TMJ) pain is associated with disrupted gut microbiome metabolites. Researchers reveal that butyrate, administered as tributyrin, alleviates pain by restoring histone acetylation and reversing gene regulatory changes in the brain.
Blood test detects tumor DNA to guide advanced cancer treatment
A blood test that detects tumor DNA circulating in the bloodstream may help select the most effective treatment options for cancer patients whose tumors have started to spread, according to one of the largest randomized controlled trials of its kind presented at the Congress of the European Society for Radiotherapy and Oncology (ESTRO 2026).
New York City's mold-removal program reduces the burden of asthma exacerbations
The New York City Housing Authority developed Mold Busters, a mold-removal program, in response to a 2013 class-action lawsuit filed by residents suffering from asthma due to mold in their apartments.
Epigenetic research links genetics and environment to mental disorders
Mental disorders, such as obsessive-compulsive disorder (OCD) and bipolar disorder, can strongly affect daily life.
Preclinical models map genetic changes behind multiple sclerosis nerve damage
More than 1 million people across the United States live with multiple sclerosis (MS), a disease that affects the brain, optic nerves and spine.
Blood metabolite patterns could reveal dementia risk in midlife
Research shows that blood metabolite profiles can indicate dementia risk, offering a potential tool for early detection and prevention of cognitive decline.
Body weight and genes directly alter gut microbiota composition
Your body weight and genes influence the types of bacteria you have in your gut. In turn, this appears to affect the risk of developing conditions such as coeliac disease and haemorrhoids.
Tuberculosis drives trillion dollar economic crisis, research shows
The impacts of tuberculosis (TB) are usually discussed in terms of public health and human suffering. Now, new research presented at the 2026 ATS International Conference shows that TB is also driving a massive global economic crisis.
Study finds pulmonary rehab empowers children with respiratory issues
New research presented at the 2026 ATS International Conference shows that pulmonary rehabilitation (PR) significantly improves functioning and quality of life in children with chronic respiratory conditions, regardless of whether lung function itself improves.
Olive waste extract may help lower fat and improve muscle markers
A polyphenol-rich olive oil byproduct may enhance muscle health, reducing fat mass and improving antioxidant markers in adults with metabolic risk factors.
Hydrogel breakthrough offers significant advance in type 1 diabetes treatment
Researchers from the University of Geneva (UNIGE) and Geneva University Hospitals (HUG) have reached a significant advance in the fight against type 1 diabetes. Using an innovative hydrogel that supports insulin-producing cells once transplanted into the body, the team successfully regulated blood sugar levels in diabetic mice.
Silent heart attacks may speed cognitive decline
Research shows hidden heart attacks accelerate cognitive decline, highlighting the need for better identification of cardiovascular risks to brain health.
New study identifies dopamine's role in reversing Alzheimer's
Imagine if patients with Alzheimer's could have their memories restored. Such a future may seem like a pipe dream, but a new study by researchers at Tohoku University, in collaboration with the University of California, Irvine, has identified dopamine dysfunction as a previously unrecognized mechanism underlying memory impairment, unlocking a potential therapeutic means of reversing cognitive decline.
Research offers clearer genetic blueprint of breast cancer variants
A study led by Dr Jason Pitt, Principal Investigator at the Cancer Science Institute of Singapore (CSI Singapore), has identified eight new "signatures" of DNA patterns (gains and/or losses) in breast cancer.




