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Once-daily oral elecoglipron produced dose-dependent weight loss in adults with obesity or overweight without diabetes, with mean reductions reaching 10.5% at 26 weeks and 11.8% at 36 weeks in the highest-dose weekly-titration group. The phase 2 trial found no evidence of a weight-loss plateau by 36 weeks, while gastrointestinal adverse events were common but generally manageable.

A new study suggests that variables linked to socioeconomic status (SES) – such as increased stress and reduced sleep – have strong relationships to brain structure and function in children.

The same memory can feel vivid and accessible one moment, yet stubbornly out of reach the next - even when the memory itself remains intact.

Chronic wasting disease (CWD) is generally associated with animals. But a new study by researchers from the University of Calgary and international collaborators explored the potential for CWD to spread from deer, elk and other cervid (hooved, plant-eating) animals to other species.

A new study finds that employer points systems, which penalize workers for absences regardless of the reason, are strongly associated with presenteeism, the practice of showing up to work while sick, and that these systems undermine the public health benefits of paid sick leave laws even in jurisdictions where such protections are on the books.

Dr. Jimmy Holder, associate professor in pediatrics at Baylor College of Medicine and Principal investigator at the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, and his team have received a grant for up to $17.25 million from Aligning Research to Impact Autism (ARIA) to become a part of the Innovative Medicine and Precision Approaches to Clinical Trials (IMPACT) Network.

While online research is a useful way to reach people who may not take part in in-person studies, researchers are increasingly concerned that fake, automated, and duplicate survey responses can reduce data quality and compromise findings.

Samantha Parker Kelleher, along with researchers at BU School of Public Health and Boston Medical Center, will examine the role of high blood pressure during the postpartum period on the risk of developing recurrent hypertensive disorders of pregnancy, such as preeclampsia and gestational hypertension.

Remote monitoring isn't a panacea for reducing readmissions across all conditions - and for some patients, clinicians should proceed with caution, clinical trial results published today in JAMA Network Open suggest.

Reducing the damage sustained by the heart during a myocardial infarction remains one of the major challenges in cardiology, even when the blocked coronary artery is reopened in a timely manner.

Adolescents who spend at least two hours a day on social media are more likely to experience depressive symptoms and poorer wellbeing, with the strongest effects in early adolescence, according to new research.

A review article now published in "Nature Reviews Genetics" brings together evolutionary theory, comparative genomics and large-scale human genetics to explain why we age and why aging rates differ among individuals and species.

Researchers at the University of California San Diego have completed a massive genetic study that identifies key biological drivers of cocaine addiction, uncovering a potential new target for treatment that resides in the liver rather than the brain.

Blood pressure management after thrombectomy for acute ischemic stroke may require a change in approach.

Daily life is shaped by the solar day, influencing when we wake up, eat, work, and sleep. Inside the body, a similar internal timing system -present in nearly every cell- known as the circadian clock, synchronizes many biological functions such as sleep, metabolism, hormone release, and even the immune system's activity.

In 2022, about 149 million children under age five worldwide suffered from childhood stunting. A critical marker of chronic undernutrition, stunting is more than a metric of physical height.

Enterobactin, a molecule produced by gut bacteria, may hold a surprising key to reducing intestinal inflammation. Not by attacking the immune system directly, but by temporarily slowing down the cell's own energy production.

Acute cardiac responses to marathon running include biomarker spikes and structural changes, though their long-term impact on heart health needs further study.

A new treatment platform developed by researchers at The University of Texas MD Anderson Cancer Center was able to deliver messenger RNA (mRNA) of the full-length DMD gene into preclinical models of Duchenne muscular dystrophy, successfully restoring the production of an important muscle protein, dystrophin, and dramatically improving muscle strength, endurance and function in vivo.

Teenage risk-taking, such as experimentation with alcohol, cannabis, nicotine and other substances, may reflect a compensatory response to lower baseline dopamine, the brain chemical for reward activity, suggests a new University of Pittsburgh School of Medicine study, published today in Nature Communications.