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Researchers linked five epigenetic clocks to distinct blood gene-expression patterns and biological pathways in 3,227 Health and Retirement Study participants. TAGS derived from these patterns often showed stronger associations with frailty, functional measures, morbidity, and mortality than their parent clocks, although further validation is needed.

Specific imbalances and disruptions to the oral microbiome have been linked to symptomatic hand arthritis by a study published online in the open access journal RMD Open.

Use of newer GLP-1 receptor agonists (semaglutide or tirzepatide) for obesity or diabetes by people with alcohol-use disorder was associated with a reduction in alcohol-related admissions to hospital, finds a study published online in the open access journal BMJ Open.

People around the world are living longer than ever before but spending more of those additional years in poor health, according to a new Global Burden of Disease (GBD) study published in The Lancet Public Health.

This perspective examines whether restoring physiological lithium levels could help protect cognition in early Alzheimer’s disease. It proposes that lithium may support cholinergic signaling and brain connectivity, but emphasizes that rigorous, safety-monitored clinical trials are needed.

In a Rwanda-based evaluation, LLM judges produced consistent and far cheaper ratings of clinical AI responses but matched local clinician ratings on only a minority of assessment criteria. They consistently missed potential demographic bias, indicating that human expert evaluation remains important despite AI’s potential role in initial screening.

Massachusetts General Hospital, a founding member of the Mass General Brigham healthcare system, has been awarded an Advanced Research Projects Agency for Health (ARPA-H) contract to develop advanced personalized genomic medicines to treat rare genetic vascular diseases.

Pregnancy puts higher oxygen demands on the body, so expectant mothers breathe significantly more air over the course of a day. When air quality is bad, they're also breathing in more harmful pollutants.

Biological sex factors into cancer in ways you might not expect. In lung cancer, a form called squamous cell carcinoma disproportionately affects males while adenocarcinoma occurs more frequently in females.

Women who experience pregnancy complications such as gestational diabetes, preeclampsia, or preterm delivery have a significantly increased long-term risk of developing peripheral artery disease (PAD) later in life, according to a new study published July 21st in the open access journal PLOS Medicine by Casey Crump of the University of Texas, US, and colleagues.

People with dementia, mild cognitive impairment, alcohol addiction, or psychiatric disorders such as schizophrenia show increased brain aging, each in specific patterns within the brain, according to a study published July 21st in the open access journal PLOS Medicine by Shile Qi from the Nanjing University of Aeronautics and Astronautics, China, and colleagues.

The American Heart Association finds that habitual coffee consumption is associated with lower risks of several cardiovascular outcomes, although most evidence comes from observational studies. Moderate intake is generally safe for most adults, while energy drinks and individual caffeine sensitivity may increase cardiovascular concerns.

Researchers analyzed dietary and metabolic data from 508 nondiabetic Mexican American children in the SAFARI family cohort, finding that higher ultra-processed food scores were associated with lower insulin sensitivity and altered early insulin secretion measures. The exploratory cross-sectional study did not establish causality, and its multiple comparisons, historical dietary data, and questionnaire-based UPF estimates warrant confirmation in longitudinal studies and trials.

A JAMA cohort study of 470 pregnant women found that lower sedentary time, higher light-intensity activity, and more daily steps across pregnancy were associated with fewer adverse pregnancy outcomes. The findings support testing practical “sit less, move more” interventions, but cannot establish cause and effect.

Wistar scientists have developed a new type of bispecific T cell engager, or BTE, that is effective against ovarian cancer in preclinical studies.

Australian research has shown for the first time that a program of swimming can be clinically effective in reducing disability from chronic low back pain.

Repeatedly losing and gaining weight may do more than frustrate dieters - it also accelerates muscle loss in middle-aged people, according to new UC San Francisco research that comes as weight-loss medications transform obesity treatment.

City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the United States with its National Medical Center ranked among the nation's top cancer centers by U.S. News & World Report, has opened an innovative Phase 2 clinical trial designed to map how tumors change as they begin to resist immunotherapy, treatment that improves the immune system's ability to fight disease.

Your brain has something surprising in common with the ocean: waves! Electrical activity washes over the brain's surface, creating what are called traveling brain waves or neural traveling waves.

Prediabetes refers to a metabolic state in which blood glucose is higher than normal but has not yet reached the diagnostic threshold for diabetes. It may involve impaired fasting glucose, impaired glucose tolerance, or elevated glycated hemoglobin A1c (HbA1c), and is closely associated with progressive β-cell dysfunction.