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Antibody-drug conjugates are rapidly expanding cancer therapies, with 19 approved globally and many more in development, but their success depends on better targets, payloads, linkers, dosing, and patient selection. The Cell review shows that next-generation ADCs could widen treatment options, but safety, resistance, tumor heterogeneity, and clinical translation remain major barriers.

A systematic review and meta-analysis of 18 studies involving 17,380 pregnant women found that common mental disorders affected about one-third of participants across studies from Africa, Asia, and South America. The analysis found strong regional variation and identified intimate partner violence as the only statistically significant risk factor, with affected women having about 2.6-fold higher odds of CMDs.

A new study led by researchers at the Harvard Pilgrim Health Care Institute, Boston University, Boston Medical Center, UMass Chan Medical School, and Brown University finds that children's mental health concerns are appearing more often during routine visits with primary care doctors.

Experiencing abuse or neglect as a child can increase the risk of being victimised by a romantic partner in adulthood, by impacting personality and mental health development, finds a new study led by University College London (UCL) researchers.

Teens may turn to marijuana use for many reasons: curiosity, stress relief, peer pressure, help with mental health, or for the positive feelings of being "high." However, there is a difference between casual use and reliance on cannabis to function.

UCLA Health researchers have identified a potential drug target for treating Fragile X syndrome, the most common genetic cause of intellectual disability and autism that affects roughly 1 in 2,000 boys.

Researchers developed ΨDNA, a DNA-based CRISPR guide that allows Cas12 enzymes to target RNA with high specificity while retaining compatibility with DNA-editing workflows. The platform detected HCV RNA in clinical samples and enabled programmable RNA knockdown, multiplex targeting, and RNA modification in human cells.

Disease-modifying therapies for type 1 diabetes are beginning to move care beyond insulin replacement by targeting immune dysregulation, beta-cell stress, and preservation of endogenous beta-cell function. Teplizumab marks a major clinical milestone, but the review emphasizes that durable metabolic remission will likely require earlier screening, better patient selection, and sequential or combination therapies.

"Why do patients with dementia or cognitive decline remain stuck in past memories?" KAIST researchers have identified, for the first time in the world, the existence of a "neural switch" in the brain that selectively retrieves the most recent memories.

Sleep complaints may be an important Alzheimer's disease risk factor in older women with a higher genetic predisposition to the disease, according to a new study from researchers at the University of California San Diego.

Polycystic Ovary Syndrome, which has just been renamed Polyendocrine Ovarian Syndrome (PMOS), is the most common hormonal and metabolic disorder affecting women of reproductive age, impacting up to 13% of this population and contributing to nearly 40% of infertility cases worldwide.

A rare and fatal brain disorder with no available treatment or cure. One that attacks the nervous system, balance, and the ability to move.

Temporomandibular joint (TMJ) pain is associated with disrupted gut microbiome metabolites. Researchers reveal that butyrate, administered as tributyrin, alleviates pain by restoring histone acetylation and reversing gene regulatory changes in the brain.

A blood test that detects tumor DNA circulating in the bloodstream may help select the most effective treatment options for cancer patients whose tumors have started to spread, according to one of the largest randomized controlled trials of its kind presented at the Congress of the European Society for Radiotherapy and Oncology (ESTRO 2026).

The New York City Housing Authority developed Mold Busters, a mold-removal program, in response to a 2013 class-action lawsuit filed by residents suffering from asthma due to mold in their apartments.

Mental disorders, such as obsessive-compulsive disorder (OCD) and bipolar disorder, can strongly affect daily life.

More than 1 million people across the United States live with multiple sclerosis (MS), a disease that affects the brain, optic nerves and spine.

Research shows that blood metabolite profiles can indicate dementia risk, offering a potential tool for early detection and prevention of cognitive decline.

Your body weight and genes influence the types of bacteria you have in your gut. In turn, this appears to affect the risk of developing conditions such as coeliac disease and haemorrhoids.

The impacts of tuberculosis (TB) are usually discussed in terms of public health and human suffering. Now, new research presented at the 2026 ATS International Conference shows that TB is also driving a massive global economic crisis.