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Researchers have discovered that SGLT2 inhibitors, a class of drugs originally developed to treat diabetes and now widely used for heart failure, work by activating a key enzyme that helps heart cells produce and use energy more efficiently.

A review of 20 non-toxic edible and medicinal fungal species found that their polysaccharides can resist digestion, interact with gut microbes, and influence microbial metabolites linked to intestinal and metabolic health. The evidence suggests potential benefits for conditions including colitis, type 2 diabetes, and obesity, although most findings currently come from laboratory and animal studies.

Why do we remember certain moments while forgetting others? Every day, our minds are bombarded with thousands of pieces of information, yet our brains have a limited capacity to consolidate these experiences into lasting memories.

Older adults who experienced food insecurity in both midlife and later life had nearly four times the risk of probable dementia as those who remained food secure, according to new University of Michigan research.

In a UK Biobank study of 183,450 postmenopausal women followed for an average of 13.3 years, hormone replacement therapy use was associated with a modestly lower risk of dementia, with stronger associations in women who had surgical menopause or shorter natural estrogen exposure. The relationship also varied by age at HRT initiation, while the observational design means the findings cannot establish that HRT prevents dementia.

A nationwide study of 218 people in the Faroe Islands examined clinical, neurological, and blood-based markers associated with persistent symptoms around six months after SARS-CoV-2 infection. Despite extensive testing, researchers found no convincing biomarker for long COVID, while a statistical association with lower INR remained within the normal clinical range and requires replication.

Higher short-term ambient UVA exposure was associated with modestly lower blood glucose levels, particularly during winter, in a large UK Biobank analysis. Separately, more frequent solarium use, used as a proxy for habitual sunlight exposure, was associated with a lower hazard of type 2 diabetes, although the observational findings do not establish causality.

When researchers at Lund University investigated how the molecule UM171 works, a molecule used to make blood stem cells multiply, they made an unexpected connection.

Mayo Clinic is a clinical collaborator on an award of up to $27.7 million from the Advanced Research Projects Agency for Health (ARPA-H) to help develop affordable, scalable gene-editing therapies for children with rare inherited immune disorders.

There is no shortage of popular diets to try, and they can generally produce weight loss if followed to the letter. But are all diet plans created equal in terms of reducing the cardiometabolic risks that come with obesity, such as Type 2 diabetes and liver disease?

Immunotherapies such as CAR T-cell therapy are used primarily to treat cancer. In the future, these patient-specific therapies, manufactured from patients' own immune cells, could also help cure autoimmune diseases.

Researchers at the Center for Regenerative Medicine (CReM) at Boston Medical Center (BMC) and Boston University (BU) have developed a scalable method for generating CD4+ helper T cells from induced pluripotent stem cells (iPSCs), overcoming a longstanding challenge in the development of stem cell-based immunotherapies.

The percentage of women in their 20s who have never been screened for cervical cancer has been increasing at a disturbing rate over the past 20 years – to the point that now, almost a third of women between the ages of 21 and 29 have never been screened.

Biologic drugs play an important role in treating cancers such as breast cancer and lymphoma, but their high costs can add to the financial burden of cancer care.

A diet that severely limits carbohydrates but is high in fat has the greatest health benefits for people with obesity compared to a Mediterranean diet or a low-fat diet, according to a clinical trial publishing August 27 in the Cell Press journal Cell Metabolism.

As the human lifespan increases, so too does the risk of developing neurological disorders such as Parkinson's disease, Alzheimer's disease, anxiety and depression.

People swimming in rivers and lakes could be putting themselves at risk of nasty skin conditions and stomach bugs, according to a new study from the University of East Anglia.

Brain diseases, including dementia, have long been studied using experimental animals such as mice.

Women with a shorter reproductive lifespan are at greater risk of developing bronchiectasis, according to a new study in the July 2026 issue of Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation, a peer-reviewed, open access journal.

Having established the effectiveness of her nanoparticle drug-delivery system for cancer immunotherapy, University of Massachusetts Amherst researcher Prabhani Atukorale, has been awarded $2.5 million from the National Institutes of Health to broaden the scope of her vaccine research to include treating those with active cancer.