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An international research team led by MDI Biological Laboratory President Hermann Haller, M.D. and postdoctoral researcher Yannic Becker, Ph.D. has discovered that a little-known molecule, heparanase 2 (Hpa2), plays a critical role in maintaining blood vessels' integrity.

Most people recognize Alzheimer's from its devastating symptoms such as memory loss, while new drugs target pathological aspects of disease manifestations, such as plaques of amyloid proteins.

Researchers have identified a neurochemical signature that sets Parkinson's disease apart from essential tremor - two of the most common movement disorders, but each linked to distinct changes in the brain.

The use of assisted reproductive technologies like in vitro fertilization is becoming more common worldwide. However, while these technologies successfully create viable embryos, a little over half of all embryos are lost because they fail to implant into the uterus.

One of the first parts of the brain affected by Alzheimer's disease is the entorhinal cortex - a region that plays a big role in memory, spatial navigation, and the brain's internal mapping system.

The European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) have just published the new international recommendations for managing dyslipidaemias. They were presented at the Annual Cardiology Congress held in Madrid from August 29th to September 1st, 2025.

Noninferiority was not demonstrated between immediate and staged complete revascularisation in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease undergoing percutaneous coronary intervention (PCI), according to late-breaking research presented in a Hot Line session today at ESC Congress 20251.

Three of the compounds demonstrated significant inhibitory effects on α-glucosidase, a key enzyme in carbohydrate digestion. The findings could pave the way for new functional food ingredients targeting type 2 diabetes.

Researchers at the University of Southampton, examining worldwide variations in funding for cancer research, say there's a pressing need to invest more in lower-income countries.

Macrophages are part of the immune system's frontline; they attack and eat invaders to protect surrounding cells. They, along with other cells, maintain intracellular conditions through macroautophagy, using autophagosomes to help digest broken cell components.

Patients with chronic fatigue syndrome/myalgic encephalomyelitis (ME/CFS) have heightened innate immune responses to bacteria, viruses, and fungi. While these responses are essential to fight infection, they can cause damage when unchecked.

Depression alters how people pursue rewards, but, conversely, whether depressive symptoms influence how people learn to avoid nonrewarding, unpleasant events is less clear.

A hormone produced by the brain, orexin, may play a central role in the functioning of the brain’s glymphatic system, which clears waste, according to a new study from the University of Oulu.

The most common type of brain tumor in children, pilocytic astrocytoma (PA), accounts for about 15% of all pediatric brain tumors.

Dual antiplatelet therapy after heart bypass surgery is not more effective than aspirin alone - and it increases the risk of excessive bleeding. This has now been shown in a study of 2,201 patients at 22 Nordic heart surgery units.

Triple-negative breast cancer (TNBC), the deadliest breast cancer subtype, disproportionately affects African American women – but until now, they were underrepresented in genomic studies aimed at identifying the genetic mutations driving the disease.

Not all acute myocardial infarction patients should be offered routine screening for the stomach ulcer bacterium Helicobacter pylori.

Black adults in the U.S. are first hospitalized for heart failure nearly 14 years earlier than white adults, reports a Northwestern Medicine study that analyzed data from more than 42,000 patients across hundreds of hospitals nationwide.

Prostate cancer is the most common malignancy among men, with over 160,000 new cases diagnosed annually in the United States.

For decades, testosterone has been recognized as the primary driver of male reproductive development and secondary sex characteristics.