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A new review from the Icahn School of Medicine at Mount Sinai and the Hospital Clínic de Barcelona provides one of the clearest roadmaps to date for understanding and treating liver cancer, one of the deadliest cancers worldwide.

An international group led by researchers from the RIKEN Center for Integrative Medical Sciences (IMS) in Japan have discovered associations between pathogenic variants of the BRCA 1 and 2 genes and four types of cancer. Published in ESMO Open, the findings expand the potential for personalized medicine to several cancer types that currently have limited treatment options and poor prognoses.

A new analytical method could improve how cancer treatments are designed - by allowing scientists to track, for the first time, exactly where inside a living cell a drug accumulates. Researchers from the University of Surrey and King's College London developed the method, which detects trace amounts of metal inside individual living cells and their internal compartments without the need to kill the cells first

Sleep deprivation has long been known to weaken the immune system. Now UF Health Cancer Institute researchers have made a startling discovery: The gut microbiota drives changes to the immune system caused by chronic sleep loss. These changes promote cancer progression, disrupt circadian rhythm and weaken the effectiveness of chemotherapy.

A new study from MIT suggests that a carcinogen that has been found in medications and in drinking water contaminated by chemical plants may have a much more severe impact on children than adults.

Researchers created a new questionnaire to measure major life changes linked to psychedelic use and found that most surveyed adults reporting naturalistic psychedelic use said psychedelics had influenced at least one major change in their lives. These changes most often involved goals, values, and spirituality, were usually rated positively, and were more commonly reported by people with more frequent use.

This Perspective reviews how AI is moving drug discovery from long, costly experimental pipelines toward earlier clinical translation, with an AI-designed TNIK inhibitor trial serving as an important proof-of-feasibility reference point. It argues that precision oncology could benefit from AI-driven integration of multi-omics, federated learning, and adaptive trial design, but only if validation, fairness, interpretability, and regulatory alignment improve.

Researchers audited five popular public-facing AI chatbots across 250 health prompts and found that 49.6% of responses were problematic, with especially weak performance on open-ended questions and in nutrition and athletic performance. The study also found poor citation quality, difficult readability, and very few refusals to answer, raising concerns about the reliability of chatbots for everyday health information.

This review argues that neurodegeneration is shaped not only by toxic protein buildup but also by immune signaling, with microglia and T cells able to either protect the brain or worsen damage depending on context. It also highlights aging, head injury, and viral infection as major forces that reshape CNS immunity and may influence disease progression and future treatment strategies.

Most oncologists say they would prescribe hormone therapy to cervical cancer patients who experience early menopause from radiation treatment, but barriers are keeping many from doing so in practice, according to a new University of Kentucky Markey Cancer Center study published in JAMA Network Open.

Researchers from the University of Bonn and University Hospital Bonn uncover vital mechanism for survival

A landmark international clinical trial led by researchers at the Centre for Addiction and Mental Health (CAMH) and University of California San Diego School of Medicine, published in The Lancet Psychiatry, has found that magnetic seizure therapy (MST) is as effective as electroconvulsive therapy (ECT)-the current gold-standard treatment for severe, treatment-resistant depression-with significantly fewer cognitive side effects. The study is the first large-scale, randomized clinical trial to directly compare MST with ECT, marking an important step toward a new treatment option for patients.

Repeated menstrual cycles may do more than trigger endometriosis. They may rewire the brain.

UCLA researchers have identified a rogue population of immune cells that quietly accumulates in aging tissues and in the livers of people with fatty liver disease. Clearing these cells, they found, dramatically reduced inflammation and reversed liver damage in mice - even while the animals remained on an unhealthy diet.

Researchers at University College Dublin have discovered a previously unknown "courier system" that cells use to deliver coherent biological messages between each other, opening new possibilities for medicine and biotechnology.

Research has shed important new light on the enemies-turned-allies that allow bacteria to exchange genes, including those linked to antimicrobial resistance (AMR).

While it was previously thought that keratinocytes (skin cells) were only passive conductors that allow the rabies virus to pass through, novel research reveals that these cells play a much more active role. The findings of a new study in the Journal of Investigative Dermatology (JID), published by Elsevier, provide direct evidence that keratinocytes can support viral replication and transmit the rabies virus to neurons. The investigators offer a mechanistic explanation for how superficial skin exposures from scratches or minor bites by dogs and bats can lead to neuroinvasion, contributing to the risk of infection.

Drugs that target amyloid beta proteins in the brain likely have no clinically meaningful positive effects, while increasing the risk of bleeding and swelling in the brain, a new Cochrane review has found.

Cancer drugs are designed to shut tumors down. But sometimes, in the very act of attacking a tumor, treatment can also help a small fraction of cancer cells become harder to kill. A new study from researchers at the Institute for Systems Biology (ISB) shows that cancer cells may begin escaping therapy much earlier - as the therapy itself triggers a stress response that drives some cancer cells into a temporary drug-tolerant state.

Efforts to identify and evaluate next-generation therapeutics for pediatric brain tumors are easily stymied by the quality and availability of laboratory models for research. To address this issue, scientists at St. Jude Children's Research Hospital developed patient-derived tumor organoids and tumor organoid xenografts that accurately reflect the biologic underpinnings of embryonal brain tumors.