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Neurodegenerative diseases affect tens of millions of people worldwide. Among these, Alzheimer's and Parkinson's diseases are the most common; in the United States alone, the Alzheimer's Disease Association and Parkinson's Foundation report roughly 7 million people with Alzheimer's and another million with Parkinson's.

For thirty years the search for autism medicines has hit the same wall, and a new peer-reviewed Perspective in Genomic Psychiatry suggests that the way around it has been sleeping at our feet the entire time.

Two proteins with opposing functions orchestrate the development and maintenance of healthy skin, Stanford Medicine researchers have found.

A comprehensive review recently published in Current Molecular Pharmacology illuminates the pivotal, multifaceted roles of lactate and its downstream protein modification, lactylation, in pancreatic ductal adenocarcinoma (PDAC).

A prespecified secondary analysis of the S-LiTE trial found that regular exercise reduced carotid artery wall thickness and circulating levels of inflammatory cytokines in adults with obesity who had already achieved substantial diet-induced weight loss. Liraglutide alone did not significantly improve these vascular or inflammatory markers, while exercise plus liraglutide also improved endothelial function biomarkers.

Researchers analyzed 6,779 stool microbiome profiles and 906 tissue samples to identify a colorectal cancer microbial signature that remained consistent across age groups, populations, and sequencing methods. The signature aligned with tumor-resident microbes, showed weaker detection for adenomas, and was inversely associated with dietary fiber intake.

A new collaborative study reports the discovery and application of a novel therapeutic strategy to selectively target EGFR and other kinases with controlled release in tumor microenvironments to improve therapeutic efficacy, with promising results.

For the immune system to effectively combat pathogens, antibody responses must be precisely controlled. So-called follicular regulatory T cells (Tfr cells) play a key role in this process by limiting excessive immune responses and helping to maintain immune tolerance.

Three out of every ten Brazilian children and adolescents complain of musculoskeletal pain (affecting bones, ligaments, and muscles).

A study recently published in Current Molecular Pharmacology has uncovered a novel mechanism by which the long non‑coding RNA PVT1 and the translation initiation factor EIF4A1 cooperate to drive gastric cancer metastasis.

'Peacemaker' immune cells could help treat diseases ranging from type 1 diabetes to neurodegeneration by restoring immune tolerance, according to a new paper in Frontiers in Science.

New research simultaneously published today in JSCAI and presented at New York Valves 2026 reported favorable one-year outcomes in patients with symptomatic severe aortic regurgitation following treatment with the investigational J-Valve Transfemoral System.

Researchers at Mayo Clinic have uncovered a previously hidden step in how the immune system prepares to fight cancer, a discovery that could help scientists develop more effective and longer-lasting cancer immunotherapies.

A study published in Current Molecular Pharmacology provides a comprehensive analysis of microRNA-29a (miR-29a) as a pivotal regulator in cancer development, and examines how natural bioactive compounds may offer a promising strategy for cancer prevention by modulating its expression.

As we age, the immune system gradually declines and becomes less effective at responding to infections and vaccines.

A study published recently in Current Molecular Pharmacology has uncovered a key mechanism linking aging to persistent pulmonary fibrosis, identifying the transcriptional regulator fPRDM16 as a potential therapeutic target.

A comprehensive review recently published in Current Molecular Pharmacology consolidates the growing evidence surrounding the Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) as a central amplifier of innate immune responses and a promising therapeutic target for a range of inflammatory diseases.

Chronic psychological stress can help tumors evade immune attack through a chain of molecular events involving gut bacteria and viruses within those bacteria, according to a study led by Weill Cornell Medicine investigators.

Markers of a new mechanism for cell death, called karyoptosis, have been found in brains of patients with Alzheimer's disease and frontotemporal dementia (FTD).

Our cells rely on tightly regulated signaling pathways to control when they grow, divide, and survive. When these regulatory systems are disrupted, cells can acquire the ability to grow uncontrollably and become cancerous.