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A Cell perspective argues that neurodegeneration can emerge from disrupted communication between neural and immune networks, with peripheral immunity, microglia, and gene-regulatory programs all shaping disease processes. The authors propose that restoring immune homeostasis and recalibrating neuroimmune circuits could create new therapeutic and diagnostic opportunities, while emphasizing that many mechanisms remain unresolved in humans.

Objective fitness tests in 13,423 Taiwanese adults aged 65 years or older linked better balance, agility, lower-body strength, and cardiorespiratory fitness with lower all-cause mortality over a median seven years. A multidomain fitness index showed the strongest association, suggesting that simple performance tests may add useful information to conventional geriatric risk assessment.

In the two-year DELISH randomized trial, adults with obesity achieved modest, sustained weight loss with either an adapted Mediterranean-style program or a commercial weight loss program. The Mediterranean-style intervention produced greater improvements in self-reported diet quality, while 24-month weight loss did not materially differ between groups.

A large Scottish birth cohort found that screen use showed limited and inconsistent associations with children’s emotional, behavioral, and social development from ages 5 to 15. Very high gaming in adolescence stood out, while several other associations weakened after adjustment, sensitivity analyses, or correction for multiple testing.

UK Biobank researchers examined whether sugar rationing during pregnancy and the first two years of life was associated with adult sweet-food preferences, sugar intake, brain structure, anxiety, and depression.

Single-cell immune profiling found that CD4 cytotoxic T lymphocytes become more abundant around age 100, showing stepwise differentiation and substantial clonal expansion. Ex vivo experiments also revealed cytokine plasticity within individual clones, supporting the hypothesis that these cells adapt to persistent antigens during healthy aging, although their direct role in longevity remains unproven.

Bad housing, high crime and poor schools are more important than transportation or income when it comes to accessing healthy food in neighborhoods historically subjected to "redlining" - the now-illegal practice once used to refuse loans, insurance or mortgages to people in certain neighborhoods that were disproportionately inhabited by racial and ethnicity minorities.

The Chagas disease parasite (Trypanosoma cruzi) undergoes a major transformation throughout its life cycle in order to infect humans and other mammals.

Interviews with patients hospitalized for heart failure, caregivers, providers, and organizational leaders highlighted several strengths of Mighty Heart (a major clinical trial examining the effectiveness of in home and telehealth-enabled visits from paramedics) that may support its adoption and implementation across health systems, a Columbia Nursing-led study finds.

Over the past five years, medications called GLP-1s have revolutionized the treatment of metabolic disorders like obesity, diabetes and fatty liver diseases.

Lung cancer screenings can save lives by detecting cancer in its early stages, but only 15% of eligible American adults have discussed the screening with their doctors, according to data analysis performed by University of Cincinnati Cancer Center researchers.

How does autism manifest in the brain? Researchers from the University of Southern Denmark and Odense University Hospital have investigated this question in a new study involving 60 adults.

Most of our brain's 100 billion neurons are created before we're born, but the trickle of neurons created in the adult brain hippocampus could be instrumental in preventing depression, suggest findings from a new study by researchers at Columbia University Vagelos College of Physicians and Surgeons.

The United Kingdom's vote to leave the European Union (EU) was associated with major changes in health care worker migration and worsening physician shortages in England, according to a new study published in JAMA Health Forum.

A study led by the University of Oxford has identified the brain mechanisms that help us work out whether the consequences we experience are caused by our own actions or by circumstances beyond our control.

A comprehensive review published in Engineering systematically outlines the regulatory capacity of silent information regulator 3 (SIRT3), a mitochondrial deacetylase termed the "head goose molecule", and its negentropic mechanism for intervening global metabolic disorders including type 2 diabetes, obesity, and steatotic liver disease.

A comprehensive review published in Engineering outlines multi-disciplinary engineering approaches addressing spinal cord injury (SCI), a debilitating central nervous system disorder triggering permanent sensory, motor, and autonomic dysfunction, and imposing heavy burdens on individuals and societies worldwide.

Australian researchers have uncovered a promising new way to tackle one of the most aggressive forms of breast cancer, raising hopes for more effective treatments to stop the disease from spreading.

​Digital media, including videogames, are a central part of leisure activities for many adolescents and adults.

Polycystic ovary syndrome (PCOS) affects approximately 6% to 20% of women of reproductive age globally and remains undiagnosed and poorly managed, especially during pregnancy, leading to significant healthcare costs.