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Fucosylation emerges as a key player in digestive inflammatory diseases and cancers
Fucosylation, a crucial post-translational modification, has emerged as a significant factor influencing digestive inflammatory diseases and cancers.
New nanoparticle drug delivery system targets the spleen for precise lupus treatment
With a $1 million Impact Award from the U.S. Department of Defense, Tianfu Wu, a University of Houston biomedical engineer, is developing a method to send medication directly to the spleen where certain immune cells cause the disease known as lupus, or Systemic Lupus Erythematosus.
Community-driven ADHD initiative leads to better outcomes for children
Innovative intervention delivered by trained community health workers – meaning nonclinical personnel with deep knowledge of the community – increased treatment utilization among participating families with children who have ADHD, according to a pilot study published in the Journal of Attention Disorders.
Mitochondrial metabolite glutathione plays key role in breast cancer metastasis
The mitochondria may be the powerhouse of the cell, but mounting evidence suggests this organelle is also a driving force behind cancer.
Prenatal exposure to common insecticide linked to brain changes and poor motor skills in children
A new study reports evidence of a link between prenatal exposure to the widely used insecticide chlorpyrifos (CPF) and structural abnormalities in the brain and poorer motor function in New York City children and adolescents.
Over-the-counter oral birth control pill improves access to contraception
Two years ago, the Food and Drug Administration approved the sale of an over-the-counter birth control pill for the first time in the United States without a prescription.
Vaccines trigger immediate changes in lymph node tissue landscape
Vaccines trigger a notably rapid response in the stromal cells of draining lymph nodes within the first hours after administration.
Polβ enzyme found to protect developing brain from harmful DNA mutations
A research group led by The University of Osaka has discovered that the DNA repair enzyme Polβ plays a crucial role in protecting the developing brain from harmful mutations.
RNA quality control protein PELOTA found to slow aging and extend lifespan
As aging progresses, the quality of DNA and proteins inside cells declines, known to be the cause of various degenerative diseases.
Inactivation of stress pathway allows ER+ breast cancer cells to evade treatment
A team of scientists at the Garvan Institute of Medical Research has discovered that inactivation of a stress pathway makes ER+ breast cancer cells ignore stress signals, allowing them to evade treatment.
Endoplasmic reticulum controls cell movement to repair tissue gaps
The body's cells change their shape to close gaps such as wounds – with part of the cell flexing depending on the curve of the gap and the organization of cell-internal structures, a new study reveals.
New molecule shows promise in treating acetaminophen-induced liver injury
Acetaminophen is one of the most common painkillers and is found in hundreds of different medications. While safe at recommended doses, acetaminophen overdose is the leading cause of acute liver injury in the U.S.
Fasting does not have the same effect on all body types, study suggests
While fasting has become a popular trend, particularly for people who hope to lose weight, new UBC Okanagan research suggests fasting does not have the same effect on all body types.
Highly sensitive individuals more prone to mental health challenges
The meta-analysis of 33 studies, the first of its kind, looked at the relationship between sensitivity and common mental health problems such as depression and anxiety.
Targeting mitochondrial biogenesis to improve outcomes in acute kidney injury
Acute kidney injury (AKI) remains a significant global health challenge, with high mortality rates and the potential for progression to chronic kidney disease.
Youth mental health crisis leads to prolonged emergency room stays
America's youth mental health crisis has escalated to the point that thousands of children primarily suffering from suicide-related behaviors and depression are stuck in hospital emergency rooms for three days or more, according to new research from Oregon Health & Science University.
Missing messenger RNA fragments unlock new immunotherapy targets in pediatric brain tumors
A new study, led by researchers at Children's Hospital of Philadelphia (CHOP), identified tiny pieces of messenger RNA that are missing in pediatric high-grade glioma tumors but not in normal brain tissues.
Study shows promising anti-diabetic potential of coffee's functional components
Three of the compounds demonstrated significant inhibitory effects on α-glucosidase, a key enzyme in carbohydrate digestion. The findings could pave the way for new functional food ingredients targeting type 2 diabetes.
Laboratory reagent contamination threatens accuracy of infectious disease research
A new study warns that contamination from laboratory reagents could be misleading scientists worldwide in their hunt for emerging infectious diseases.
Muscle stem cells show ability to transform and heal broken bones
When bones break and there is extreme tissue loss--such as after a car accident or a battlefield injury--current treatments don't often lead to effective healing.