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This review argues that gut microbes and the metabolites they produce, especially SCFAs and TMAO, may shape how the heart responds to myocardial infarction through epigenetic pathways such as DNA methylation, histone modification, and non-coding RNAs. It also outlines potential intervention routes, including diet, probiotics, postbiotics, and metabolite-targeted therapies, while noting that much of the evidence remains translational and not yet clinically definitive.

Researchers built the Extreme Environment Microbiome Catalog from 78,213 genomes across global extreme habitats, revealing major taxonomic and biosynthetic novelty, including 32,715 representative species, nearly 4 billion non-redundant genes, and 163,693 biosynthetic gene clusters. They then used protein language models to identify 3,032 candidate non-toxic antimicrobial peptides, with 84 of 100 synthesized peptides showing antibacterial activity and low cytotoxicity in the 50 tested in mammalian cells.

In Danish adults aged 40 years or older, laboratory-confirmed influenza was linked to a sharp short-term rise in first-time heart attack and stroke risk, especially in the first 7 days after infection. Prior same-season influenza vaccination was associated with about half the excess cardiovascular risk among infected individuals, suggesting possible protection even in breakthrough cases.

A new ACC/AHA dyslipidemia guideline and editorial argue that guideline development is rigorous but can lag behind fast-moving science, using the VESALIUS-CV trial as a clear example. The trial showed that intensive LDL cholesterol lowering with evolocumab reduced cardiovascular events in high-risk patients without prior heart attack or stroke, with implications for future guideline updates.

Mayo Clinic researchers have developed a new method to identify which proteins are most likely to trigger an immune response - a discovery that could help improve transplant care, regenerative medicine and other areas where the immune system plays a critical role.

Mayo Clinic researchers developed an experimental nanotherapy that delivers two cancer drugs directly to brain tumors, according to a study published in Communications Medicine.

For decades, scientists have been carefully unraveling the role of genes in disease by examining how small variations in a person's genetic code can shape lifelong risk of developing common conditions such as cancer, diabetes, or heart disease.

Early problems with language can have a lasting negative impact on social and emotional development. Building on this foundation, a new groundbreaking study from Florida Atlantic University and Aarhus University in Denmark tests the hypothesis that unsupervised, solitary screen time during early childhood increases the likelihood that language difficulties will lead to socioemotional difficulties.

Princeton researchers have revealed new links between high-fat diets and aggressive breast cancer, demonstrating the important role fat plays in making some cancers more invasive.

A new study has found that metformin, a widely prescribed diabetes drug, may mimic one of exercise's core biological effects in men with prostate cancer, raising levels of a molecule tied to energy balance and weight control even when patients are inactive.

Some therapies used to treat cancer may increase the risk of later developing cancers that affect the blood.

The trend for unvaccinated blood donations raises concerns about patient safety and resource efficiency, emphasizing the need for better transfusion protocols.

Irregular sleep timing significantly impacts heart health, with inconsistent bedtimes linked to a higher risk of major cardiovascular events over a decade.

Plastic pollution has become one of the defining environmental issues of modern life, and microplastics are now known to enter the body through food, drink, and air.

Japan's transition to a super-aged society is intensifying pressure on healthcare and social security spending.

New research from Michigan State University challenges the popular assumption that narcissists gradually damage their relationships over time.

In new research to be presented at this year's European Congress on Obesity (ECO2026) in Istanbul, Turkey (12-15 May), researchers show an increased risk of stroke in young adulthood for children of low birthweight, independent of their body mass index (BMI) as young adults or gestational age at birth.

People of color who are also part of sexual and gender minority groups face unique challenges shaped by overlapping forms of discrimination. While much research has focused on the mental health risks they experience, far less has explored how people of these multiple identities build strength and resilience.

Myotonic dystrophy type 1 (DM1) is the most common cause of adult-onset muscular dystrophy, a genetic disorder that leads to muscle weakness and wasting, but also affects the brain, the gastrointestinal tract and the heart.

A novel vaccine platform has been developed to induce broad, protective immunity against numerous influenza virus infections, showing promise as an effective mucosal vaccine strategy, according to a study published by researchers in the Institute for Biomedical Sciences at Georgia State University.