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Early brain connectivity predicts recovery after traumatic brain injury
After traumatic brain injury (TBI), some patients may recover completely, while others retain severe disabilities.
Reframing the role of MCL1 in cancer signaling and metabolism
A study by the Mildred Scheel Early Career Center group led by Dr. Mohamed Elgendy at the TUD Faculty of Medicine provides fundamental insights into cancer biology.
A senescence-based therapeutic approach for temporal lobe epilepsy
Temporal lobe epilepsy, which results in recurring seizures and cognitive dysfunction, is associated with premature aging of brain cells.
Research highlights a potential therapeutic strategy for vascular dementia
A possible new treatment for impaired brain blood flow and related dementias is on the horizon.
Altered stress signaling helps explain relapse in alcohol use disorder
A new study by Scripps Research reveals that alcohol dependence disrupts two signaling pathways in a stress-related part of the brain-and offers insights on developing drugs to treat this condition.
Precision immunotherapy for TRBC2-positive T-cell malignancies
Researchers at the Johns Hopkins Kimmel Cancer Center's Ludwig Center developed a new treatment that selectively targets TRBC2-positive T-cell cancers, expanding a precision approach they established in 2024 for TRBC1-positive tumors.
Fatty diets reprogram hepatocytes and increase liver cancer risk
One of the biggest risk factors for developing liver cancer is a high-fat diet. A new study from MIT reveals how a fatty diet rewires liver cells and makes them more prone to becoming cancerous.
Rethinking Mendelian assumptions in inherited retinal degenerations
A new study challenges what's long been assumed about genetic variants thought to always cause inherited blindness.
Remodeling the tumor microenvironment to unlock CAR-T cell potential
Chimeric antigen receptor T (CAR-T) cell therapy has revolutionized hematologic cancer treatment, but its efficacy in solid tumors remains limited by poor infiltration into the complex tumor microenvironment (TME).
Probiotic supplementation restores beneficial gut bacteria in breastfed infants
In recent years, scientists have learned that key beneficial infant gut bacteria Bifidobacterium infantis are disappearing from infants in high-resource areas such as the United States and Europe.
Engineered extracellular vesicles enable antigen-specific regulatory T cell induction
A research team at the Nano Life Science Institute (WPI-NanoLSI) and the Faculty of Medicine at Kanazawa University has developed a new class of engineered extracellular vesicles (EVs) capable of inducing antigen-specific regulatory T cells (Tregs), the immune cells that play a central role in suppressing excessive immune responses.
ARB drugs lead to better blood pressure treatment adherence
Patients who start their blood pressure treatment with ARB drugs continue with the same medicine to a greater extent than patients who start out with other drugs.
Popular video games may offer meaningful emotional benefits for young adults
A new study published by JMIR Serious Games reports that popular video games, such as the Super Mario Bros. and Yoshi games, may offer meaningful emotional benefits for young adults.
Women may derive greater long-term benefits from coronary artery bypass grafting compared with stents
Women with severe coronary heart disease causing narrowing or blockages in the arteries may derive greater long-term benefits from coronary artery bypass grafting compared with percutaneous coronary intervention, also known as stenting, according to a large study by Weill Cornell Medicine investigators.
Homer1 gene plays a critical role in shaping attention
Attention disorders such as ADHD involve a breakdown in our ability to separate signal from noise. The brain is constantly bombarded with information, and focus depends on its ability to filter out distractions and detect what matters.
Community awareness campaign helps improve early diagnosis of colorectal cancer in low-resource regions
In low-resource regions such as Nigeria, most people with colorectal cancer are diagnosed too late for curative treatment options.
Splicing regulator U2AF1 promotes angiogenesis in cardiac injury
A study published in Engineering shows that a protein called U2 small nuclear RNA auxiliary factor 1 (U2AF1), released by immune cells known as macrophages, helps grow new blood vessels in the heart after a myocardial infarction (MI) by altering how the gene Yap1 is spliced.
Study charts the escalating spread of resistant bacteria and fungi
The success of modern medicine rests on the ability to control infections. But decades of antibiotic overuse—in hospitals, communities, and farms—have fueled a global surge in resistant microbes.
Getting a dog for the first time boosts walking and remote social ties
First-time dog owners in Japan showed significant increases in walking activity and non-face-to-face social contact over one year compared with non-dog owners. No significant changes were observed in vigorous activity or face-to-face social contact, highlighting specific behavioral associations rather than broad lifestyle shifts.
Blood metabolite profiling outperforms BMI in predicting pregnancy complications
This study shows that a blood-based metabolomic signature linked to maternal BMI predicts gestational diabetes and preeclampsia more strongly than BMI alone, particularly in late pregnancy. A subset of 16 metabolites statistically mediates the BMI–gestational diabetes association, highlighting metabolic pathways that may improve prenatal risk stratification.




