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Metabolic diseases have reached epidemic proportions in our society, driven by a sedentary lifestyle coupled with circadian misalignment - a desynchrony between our intrinsic biological clocks and environmental signals.

Researchers at Karolinska Institutet have discovered that the nervous system's own immune cells help protect the spinal cord from age-related damage.

This perspective argues that Parkinson’s disease may involve functional iron deficiency, where bioavailable iron is limited despite normal or elevated total iron in the brain. The authors propose that iron sequestration, not iron toxicity alone, may impair dopamine synthesis and neuronal survival.

This comprehensive review synthesizes a decade of human and animal research to explain how the gut and brain communicate through hormonal, neural, immune, and microbial pathways. It highlights how disruptions in these pathways contribute to gastrointestinal, metabolic, and neurological disorders, and how modern therapies are beginning to exploit gut–brain signaling for clinical benefit.

This review synthesizes clinical, genetic, and mechanistic evidence showing that suPAR and related uPAR fragments are strongly associated with kidney, cardiovascular, and metabolic disease risk. It highlights suPAR as a stable biomarker of innate immune activation with potential pathogenic roles, while underscoring major gaps in assay standardization and therapeutic validation.

Australian researchers have uncovered how a particular strain of a diarrhea-causing parasite managed to infect more animal species, offering new insights into how parasitic infections emerge and spread to people.

For centuries, Borago officinalis - commonly known as Borage or the Starflower - has been a staple of traditional medicine.

Researchers at The University of Texas at El Paso have found unusually high levels of parasitic infection in the insects that transmit Chagas disease in the Borderlands.

Sleeping in on the weekend to catch up on sleep lost during the week may be good for adolescents' mental health, according to new research by the University of Oregon and the State University of New York Upstate Medical University.

A new database targeting chronic urinary tract infections (UTIs) – a long-overlooked condition that may begin in childhood – is set to help researchers uncover why millions of women and girls worldwide suffer from infections that defy treatment and stump microbiologists.

In a revealing Genomic Press Interview published today in Genomic Psychiatry, Dr. Maria Margarita Behrens recounts an extraordinary scientific journey that wound through four countries and multiple disciplines before arriving at fundamental questions about how the brain develops and what goes wrong in psychiatric disorders.

Researchers at the UNC School of Medicine and the UNC Eshelman School of Pharmacy have made a breakthrough that could modernize treatment for glioblastoma, a fast-growing and deadly form of brain cancer.

For over a century, Alzheimer's disease (AD) has been considered irreversible. Consequently, research has focused on disease prevention or slowing, rather than recovery.

Nurses in critical care units who perceive higher levels of teamwork with their colleagues are more likely to take breaks during their shifts, according to new research from The Center for Health Design published in American Journal of Critical Care (AJCC).

About half of older men suffer from sleep problems, back pain or both, according to Soomi Lee, associate professor of human development and family studies at Penn State.

A groundbreaking new study from Bar-Ilan University shows that one of sleep's core functions originated hundreds of millions of years ago in jellyfish and sea anemones, among the earliest creatures with nervous systems.

Simple pharmaceutical interventions could help older brains cope with memory impairment and recovery after surgery, new studies in mice suggest.

A new study co-led by the Southern California Superfund Research and Training Program for PFAS Assessment, Remediation and Prevention (ShARP) Center and the University of Hawai'i has linked certain common "forever chemicals" to a higher risk of liver disease in adolescents.

An elevated neutrophil-to-lymphocyte ratio (NLR) is significantly associated with increased risk of depressive disorder (DD) and may also correlate with suicide risk among individuals with DD, according to a systematic review and meta-analysis published in the November issue of Harvard Review of Psychiatry, part of the Lippincott portfolio from Wolters Kluwer.

New research from the University of East Anglia (UK) reveals the hidden struggles experienced by the brothers and sisters of people with Prader-Willi syndrome.