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Researchers from the University of North Carolina at Chapel Hill's Institute for Global Health and Infectious Diseases, the Ethiopian Public Health Institute (EPHI), Brown University, the University of Notre Dame, and Ethiopia's Ministry of Health have found that malaria parasites carrying genetic markers associated with resistance to frontline antimalarial medicines and commonly used diagnostic tests are becoming increasingly prevalent across Ethiopia.

Type 2 diabetes has traditionally been a disease that has developed mostly in middle-aged and older adults.

Black people in Canada who want to donate blood face barriers to doing so, despite a critical need for specific blood types to treat sickle cell disease, according to new research published in CMAJ.

Research published today in Diabetologia by Amsterdam UMC and the University of Ghana reveals that type 2 diabetes manifests in two fundamentally different ways depending on a patient's body mass index (BMI).

Driven by the potential advantages in bone stock preservation and easier implant removal during revision surgery, the use of cementless short-stem implants in shoulder arthroplasty has increased in recent years.

Low- and middle-income countries (LMICs) bear a disproportionate burden of gynecologic malignancies-cancers of the cervix, endometrium, ovary, vagina, and vulva.

Long‑term outcomes after liver transplantation remain hampered by complications linked to intensive immunosuppression—infections, cardiovascular events, kidney dysfunction, and metabolic disorders affect 10% to 40% of recipients.

Unexpected staff shortages in ambulance services are costing lives, with patients significantly more likely to die within 24 hours when ambulance crews are unexpectedly off sick, according to new research from the University of Surrey and the University of York.

A prespecified analysis of 17,604 SELECT participants found that higher baseline hsCRP was associated with greater risks of major cardiovascular events and death in people with overweight or obesity and established cardiovascular disease. Semaglutide produced rapid and sustained reductions in hsCRP, with changes emerging before substantial weight loss, although the study could not establish whether reduced inflammation directly mediated its cardiovascular benefits.

A Cell perspective argues that neurodegeneration can emerge from disrupted communication between neural and immune networks, with peripheral immunity, microglia, and gene-regulatory programs all shaping disease processes. The authors propose that restoring immune homeostasis and recalibrating neuroimmune circuits could create new therapeutic and diagnostic opportunities, while emphasizing that many mechanisms remain unresolved in humans.

Objective fitness tests in 13,423 Taiwanese adults aged 65 years or older linked better balance, agility, lower-body strength, and cardiorespiratory fitness with lower all-cause mortality over a median seven years. A multidomain fitness index showed the strongest association, suggesting that simple performance tests may add useful information to conventional geriatric risk assessment.

In the two-year DELISH randomized trial, adults with obesity achieved modest, sustained weight loss with either an adapted Mediterranean-style program or a commercial weight loss program. The Mediterranean-style intervention produced greater improvements in self-reported diet quality, while 24-month weight loss did not materially differ between groups.

A large Scottish birth cohort found that screen use showed limited and inconsistent associations with children’s emotional, behavioral, and social development from ages 5 to 15. Very high gaming in adolescence stood out, while several other associations weakened after adjustment, sensitivity analyses, or correction for multiple testing.

UK Biobank researchers examined whether sugar rationing during pregnancy and the first two years of life was associated with adult sweet-food preferences, sugar intake, brain structure, anxiety, and depression.

Single-cell immune profiling found that CD4 cytotoxic T lymphocytes become more abundant around age 100, showing stepwise differentiation and substantial clonal expansion. Ex vivo experiments also revealed cytokine plasticity within individual clones, supporting the hypothesis that these cells adapt to persistent antigens during healthy aging, although their direct role in longevity remains unproven.

Bad housing, high crime and poor schools are more important than transportation or income when it comes to accessing healthy food in neighborhoods historically subjected to "redlining" - the now-illegal practice once used to refuse loans, insurance or mortgages to people in certain neighborhoods that were disproportionately inhabited by racial and ethnicity minorities.

The Chagas disease parasite (Trypanosoma cruzi) undergoes a major transformation throughout its life cycle in order to infect humans and other mammals.

Interviews with patients hospitalized for heart failure, caregivers, providers, and organizational leaders highlighted several strengths of Mighty Heart (a major clinical trial examining the effectiveness of in home and telehealth-enabled visits from paramedics) that may support its adoption and implementation across health systems, a Columbia Nursing-led study finds.

Over the past five years, medications called GLP-1s have revolutionized the treatment of metabolic disorders like obesity, diabetes and fatty liver diseases.

Lung cancer screenings can save lives by detecting cancer in its early stages, but only 15% of eligible American adults have discussed the screening with their doctors, according to data analysis performed by University of Cincinnati Cancer Center researchers.