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Antidepressant fluoxetine alters brain energy use and boosts neural plasticity
A new study shows that the widely used antidepressant fluoxetine does more than boost serotonin levels: it changes how brain cells manage their energy and rebuild their connections, potentially helping the brain "loosen up" and adapt during depression treatment.
Mapping 100 years of bacterial evolution reveals key spreaders of antibiotic resistance
The genetic culprits responsible for the spread of multidrug resistance (MDR) in bacteria have been identified by new research mapping 100 years of bacterial evolution.
Analysis shows potential impact of deep NIH budget cuts on future drug development
Gleevec, a cancer drug first approved for sale in 2001, has dramatically changed the lives of people with chronic myeloid leukemia.
Lysosomal activity in worms linked to transgenerational extension of lifespan
In the Wang Lab, it's not unusual for worms to live for a long time. HHMI Janelia Research Campus Senior Group Leader Meng Wang and her team study longevity. They've shown that by overexpressing an enzyme in the lysosomes of the roundworm C. elegans, they can extend the worm's life by up to 60 percent.
Frontline clinicians report trauma patterns in Gaza exceeding previous warzones
A British led study published by The BMJ today provides detailed data on the pattern and severity of traumatic injuries and medical conditions seen by international healthcare workers deployed to Gaza during the ongoing military invasion.
Gladstone researchers expand mission to tackle emerging infectious threats
From influenza and COVID-19 to HIV, viruses continue to pose a serious danger to global health.
Study explains how genetics and lifestyle combined to keep a 117-year-old healthy
Scientists conducted a multiomics study of the world’s oldest verified person (117 years), uncovering protective genetic, immune, metabolic, microbiome, and epigenetic traits that supported her exceptional longevity. These findings highlight how aging and disease may, under rare circumstances, be decoupled.
Babies living with dogs show better lung function and reduced asthma rates
Babies exposed to dog allergens in the home have a lower risk of developing asthma by the age of five years, according to research that will be presented at the European Respiratory Society (ERS) Congress in Amsterdam, the Netherlands.
UdeM studies make a major breakthrough in predicting neurodegenerative diseases
An international research team led by Université de Montréal medical professor Shady Rahayel has made a major breakthrough in predicting neurodegenerative diseases.
Emergency departments emerge as key entry point for hospice and palliative care
One-third of Americans will visit an emergency department, or ED, within a month of their death. While EDs are primarily purposed to provide emergent care, they're increasingly becoming an initial touchpoint for hospice and palliative care, or HPC, referrals and consultations, according to a new study from several researchers at Henry Ford Health + Michigan State University Health Sciences.
Alcohol raises dementia risk at every level of drinking, genetic study shows
Researchers using two major cohorts and Mendelian randomization found that alcohol consumption, whether light or heavy, raises the risk of dementia. Genetic evidence shows no safe level of drinking, challenging the belief that moderate intake protects brain health.
Organophosphate pesticide exposure linked to reduced sperm quality in healthy men
This pilot study found that urinary metabolites of organophosphate pesticides were linked to reduced sperm motility in healthy young men, though results were preliminary. Oxidative stress did not explain the association, suggesting other biological pathways may be involved.
Do fitness apps change behavior in the long run?
A 24-month study of over 516,000 Canadians found that a commercial fitness app offering micro-incentives led to very small but sustained increases in daily step counts. Low-active users benefitted most, while very active users showed declines, highlighting the complexity of long-term app engagement.
Mount Sinai study maps protein networks driving Alzheimer’s disease pathogenesis
A new study led by the Icahn School of Medicine at Mount Sinai offers one of the most comprehensive views yet of how brain cells interact in Alzheimer's disease, mapping protein networks that reveal communication failures and point to new therapeutic opportunities.
COVID-19 linked to long-lasting reductions in smell even without noticeable symptoms
People who suspect that their sense of smell has been dulled after a bout of COVID-19 are likely correct, a new study using an objective, 40-odor test shows. Even those who do not notice any olfactory issues may be impaired.
Healthy habits linked to younger brain age
Your chronological age may say 65, but your brain could be acting a decade younger - or older - depending on your life experiences.
Depression and psychosis rise after childbirth while suicide risk declines
Depression and psychosis are more common in women after childbirth than before, but the risk of suicide attempts decreases. This is shown by two new studies from Karolinska Institutet.
Discovery of EP2 receptor opens path to pain relief without blocking inflammation
Scientists at the NYU Pain Research Center have identified which receptor in prostaglandins-the hormone-like substance targeted by common painkillers-causes pain but not inflammation.
Study uncovers how lymphatic endothelial cells assist in generating robust immune memory
A study published today in Nature Communications describes how lymphatic endothelial cells assist in generating robust immune memory, offering new insights into how the immune system functions.
UPR modulators show promise in treating cancer-related bone disease
Before a chain of amino acids can become an active and useful protein, it must be processed and folded into the appropriate conformation.




