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Study finds link between epimutations in BRCA1 gene and triple-negative breast cancer risk
Research reveals that around 20 per cent of all cases of the most severe form of breast cancer may arise from the small group of normal tissue cells carrying an epimutation of a specific gene.
IDEA trial: Skipping radiotherapy safe for younger postmenopausal patients with early-stage breast cancer
Almost all postmenopausal patients aged 50-69 years with stage I hormone receptor (HR)-positive breast cancer and low scores on a common genetic test who opted out of adjuvant radiotherapy were disease free five years after surgery, according to results from the IDEA clinical trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.
Exercise may become part of standard treatment for metastatic breast cancer, study suggests
Among patients with metastatic breast cancer, those who took part in a nine-month structured exercise program reported less fatigue and an improved quality of life compared to those who did not undergo the exercise program, according to results from the PREFERABLE-EFFECT trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.
Working night shifts associated with higher occurrence of disordered sleep
Sleep is critical for daytime and neurocognitive functioning, as well as physical and mental health. When people work shifts – in 2015, 21% of workers in the European Union did – their circadian sleep-wake rhythms are commonly disrupted.
Can oral contraceptive therapy improve the vaginal microbiome in women with PCOS?
The impact of the contraceptive medication-induced change in hormonal levels on the vaginal microbiome.
Associations between low-inflammatory diets and diabetes risk
Associations between a low-inflammatory diet and type 2 diabetes (T2D) risk.
Promising candidate medication for preventing and reversing fentanyl-induced overdose
Researchers assessed CSX-1004, a monoclonal antibody (mAb), for its efficacy in reversing fentanyl overdose based on its high affinity for fentanyl, positive animal model results, and safe pharmacokinetic profile, positioning it as a potential solution in the opioid crisis.
What's my age again? Predicting disease and aging effects by studying organ aging using plasma proteomics data
Researchers performed a proteomic analysis to identify serologic indicators of organ aging and disease.
The association between viral infections and glioma risk
The causal relationship between viral infection and glioma.
Psychotria malayana Jack leaf extract could effectively treat diabetes with lower toxicity
Psychotria malayana Jack leaf extract (OE) to evaluate its anti-diabetic, anti-inflammatory, and antioxidant properties.
Identification of avoidable risk factors for Parkinson’s Disease
Avoidable risk factors for Parkinson’s Disease (PD).
Does hearing impairment increase the risk of dementia?
Association between hearing impairment and future dementia.
Understanding deprivation measures: A key to equitable public health resource allocation
Over the course of the pandemic, COVID-19 hit Black communities and communities of color particularly hard.
PFAS exposure linked to weaker bones in young people
Per- and polyfluoroalkyl substances (PFAS), manufactured chemicals used in products such as food packaging and cosmetics, can lead to reproductive problems, increased cancer risk and other health issues.
Ashwagandha extracts show promise in reducing stress hormones, study suggests
A systematic review reveals that Withania somnifera (Ashwagandha) extracts can effectively reduce cortisol levels in the short term, offering a natural alternative for stress management, though long-term effects remain unexplored.
Study reveals no 'one-size-fits-all' balance between solitude and socializing for well-being
Study in Scientific Reports finds no 'optimal' balance between solitude and socializing for mental health, suggesting that individual preferences and motivations play a crucial role in well-being.
New research may pave the way for treatment of vaginal yeast infections
New research could one day pave the way for the treatment of vaginal yeast infections, by shedding new light on how microbes in the body absorb zinc.
Thalamus-targeted deep brain stimulation improves cognition in brain injury patients
Study shows that deep brain stimulation (DBS) of the central lateral thalamic nuclei and medial dorsal tegmental tract improves executive function in patients with moderate-severe traumatic brain injury, offering a potential new treatment approach.
Excessive smartphone use linked to mental health risks in adolescents, study indicates
A study in PLOS ONE involving over 50,000 Korean adolescents reveals that those using smartphones for more than 4 hours daily have higher rates of mental health issues and substance use, while moderate use may be beneficial.
Dietary intervention with cooking instructions boosts kidney health in African-Americans, study finds
Study finds that providing fruits, vegetables, and cooking instructions to African-American adults with early-stage chronic kidney disease significantly improves kidney health, highlighting the importance of dietary guidance in disease management.