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Investigators from the Mass General Brigham Cancer Institute have found that adults with newly diagnosed acute myeloid leukemia (AML) receiving a less-intensive combination of azacitidine and venetoclax had more than twice as much time before treatment failed, the leukemia returned or worsened, or they died, compared with patients receiving intensive chemotherapy.

Bright light therapy lamps can improve sleep, activity levels and circadian rhythms of older adults in urban areas who have diminished exposure to natural light, a new study from the University of Surrey reports.

The influence of the hormone progesterone on mood is well known. Now researchers from the University of Barcelona have shown how higher levels of progesterone during the menstrual cycle are linked to less distinct patterns of activity in areas of the brain involved in controlling emotions.

For people with moderate to severe asthma, increasing the number of daily steps may be as effective as structured aerobic training sessions for managing the disease.

A shared biological secret that helps explain chronic exhaustion in conditions including long Covid and PTSD has been discovered by researchers at the University of East Anglia and Oxford BioDynamics.

Alcohol-attributable cancer deaths in the U.S. doubled between 1990 and 2023, a new study found. The study also revealed that alcohol-linked cancer deaths are not limited to older adults or liver cancer.

A longitudinal study of 964 women found that blood markers of gut epithelial barrier dysfunction and microbial product translocation began to rise around 2 to 2.5 years before the final menstrual period and remained elevated after menopause. The findings suggest that changes in gut barrier integrity may form part of the biological transition through menopause and could help explain links between menopause, inflammation, and later health outcomes.

A Journal of Clinical Investigation Viewpoint highlights growing evidence that GLP-1 receptor agonists, particularly semaglutide, may reduce alcohol consumption and some other substance-related outcomes by acting on brain systems involved in reward, motivation, stress, and emotion. However, the authors caution that efficacy for substance use disorders is not yet firmly established and call for further research into optimal dosing, treatment duration, patient selection, mechanisms, and effects across different addictions.

In a prospective analysis of 104,806 adults from the NutriNet-Santé cohort, greater differences in meal timing between weekdays and weekends were associated with higher risks of cardiovascular disease and coronary heart disease in men over a median 8.1 years. The associations were strongest when weekend eating shifted earlier, while delayed weekend eating was linked specifically to coronary heart disease, with no association detected for cerebrovascular disease.

Children with one of the deadliest forms of brain cancer may benefit from an additional course of radiation therapy after their disease returns, according to new research from the Icahn School of Medicine at Mount Sinai.

Researchers blocked a naturally occurring molecule to reverse pulmonary arterial hypertension in preclinical models, a finding that could point to a new treatment approach for people with a rare and often fatal lung disease.

A scientist at Cincinnati Children's who has hunted for decades for ways to shrink the painful and disfiguring nerve tumors caused by neurofibromatosis type 1 (NF1) has made a new breakthrough in the quest.

Columbia University will award the 2026 Louisa Gross Horwitz Prize to Adrian Bird and Huda Zoghbi for their pioneering work on epigenetic regulation in the nervous system and its role in human neurological disease, particularly Rett syndrome.

Mental health conditions, such as posttraumatic stress disorder (PTSD), substance abuse, depression and anxiety, can develop after people experience trauma.

A clot forms. Blood flow to the brain is blocked. Starved of oxygen, neurons begin to die.

A new real-world observational study has found that adding adjuvant immunotherapy after surgery does not significantly improve survival outcomes in patients with resectable non-small cell lung cancer (NSCLC) who have already achieved a pathological complete response (pCR) following neoadjuvant chemoimmunotherapy.

Scientists study the underlying causes of a disease or test new potential drugs in animal models or cells obtained from human biopsy specimens before clinical trials.

A National Institutes of Health (NIH)-funded study has shown that the GLP-1 drug semaglutide extended lifespan in older, healthy mice by tempering the detrimental effects of aging.

Men diagnosed with nonmetastatic prostate cancer can generally expect to live for many years after their diagnosis. However, cardiovascular disease and other cancers remain important threats to their long-term health.

A genetic marker already used to flag risk of a life-threatening reaction to the antibiotic vancomycin also identifies patients at risk of that reaction to lamotrigine - and it is missing from the gene panels clinicians order before prescribing the drug, Vanderbilt Health-led researchers report Sept. 2 in JAMA Network Open.