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Genetic links between type 2 diabetes and subcortical brain structure revealed
Recently, the team led by Chief Physician Quan Zhang and Associate Professor Feng Liu at Tianjin Medical University General Hospital systematically evaluated the genetic associations between type 2 diabetes mellitus and subcortical brain structures using large-scale genome-wide association summary statistics and advanced statistical genetic methods.
Egr-1 gene identified as crucial regulator of regulatory T cells in multiple sclerosis
Autoimmune diseases, such as multiple sclerosis (MS), inflammatory bowel disease (IBD), and rheumatoid arthritis (RA), affect millions of people worldwide.
Researchers develop novel engineered extracellular matrix to improve cartilage repair
Recently, a research team from Chongqing Medical University, led by Prof. Wei Huang, Dr. Wei Bao, and Dr. Yiting Lei, has successfully developed a novel engineered extracellular matrix (eECM) to address the challenge of cartilage repair.
Intestinal microbiome and metabolite profiles linked to chemotherapy response in breast cancer
Announcing a new article publication for BIO Integration journal. Imbalances in the intestinal microbiome are closely associated with the occurrence and development of cancer, and can affect tumorigenesis by influencing the inflammatory response, regulating the immune system, producing specific metabolites, and participating in tumor signaling pathways.
Monoclonal antibody delivered through the nose blocks hay fever in mice
Approximately 40% of the European population are allergic to pollen, and their symptoms cause an estimated loss of 100 million school- and workdays every year.
Toxic metals in breast milk linked to infant growth problems in Guatemala
Research led by the University of Arizona Health Sciences found a potential link between growth problems among infants and high levels of toxic metals and other elements in the breast milk of Mayan women in Guatemala's Lake Atitlán watershed region.
Maltreatment in early childhood tied to lasting behavioral challenges
Childhood maltreatment leaves deep and lasting marks that have far-reaching consequences, extending beyond immediate trauma and affecting survivors in ways that are often invisible and misunderstood.
Children face similar risk of dehydration and hyperthermia in extreme heat as adults
New research from the University of Sydney has found that children are at a similar risk of dehydration and hyperthermia in extreme heat as adults, contradicting previous advice that children are more susceptible to heat-related illnesses.
Researchers create over 400 types of nerve cells from stem cells
Nerve cells are not just nerve cells. Depending on how finely we distinguish, there are several hundred to several thousand different types of nerve cell in the human brain according to the latest calculations.
Myopenia identified as key contributor to muscle loss in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects individuals across all ages and genders.
Study confirms high survival rates for men with low-risk prostate cancer
New research in the July 2025 issue of JNCCN-Journal of the National Comprehensive Cancer Network finds that for people diagnosed with nonmetastatic low-risk prostate cancer later in life, and treated according to NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines), 90% were likely to survive their cancer for their remaining life-expectancy.
Hydrogels could be key to safer, smarter cancer drug delivery
Hydrogels could revolutionize cancer treatment by facilitating targeted drug delivery, reducing adverse effects, and enhancing therapeutic effectiveness.
Weekly injectable drug offers hope for Parkinson's patients
A new weekly injectable drug could transform the lives of more than eight million people living with Parkinson's disease, potentially replacing the need for multiple daily tablets.
Children from deprived areas face worse outcomes in intensive care
Children from ethnic minority backgrounds and those living in areas with higher levels of child poverty were more likely to die in intensive care than White children and those from the least deprived areas.
Frequent gabapentin use linked to higher dementia and cognitive impairment risk
Receiving six or more prescriptions of the drug gabapentin for low back pain is associated with significantly increased risks of developing dementia and mild cognitive impairment (MCI)--29% and 85%, respectively-finds a large medical records study published online in the journal Regional Anesthesia & Pain Medicine.
Early-onset diabetes rates soar among young adults in Sweden
Early-onset type 2 diabetes nearly doubled in Sweden between 2006 and 2021, with the sharpest increases among young adults, ethnic minorities, and those with lower education. Projections show early-onset T2D could triple by 2050, posing a major public health challenge.
Distressed births linked to mental and physical problems later in life
A research study crafted by two University of Miami Patti and Allan Herbert Business School professors establishes a strong correlation between distressed births and experiencing mental and physical problems later in life.
TMP-SMX in early pregnancy increases risk of birth defects, new study shows
A large US cohort study found that using trimethoprim-sulfamethoxazole (TMP-SMX) for UTI in the first trimester of pregnancy was associated with a higher risk of congenital malformations compared to β-lactam antibiotics. No increased risk was seen with nitrofurantoin or fluoroquinolones.
Mitochondria and peroxisomes work together to defend against cell damage
An international team led by researchers at The Hospital for Sick Children (SickKids), Princess Margaret Cancer Centre, Dalhousie University, the University of Exeter (UK) and the Medical University of Vienna (Austria) has uncovered a surprising way compartments within cells work together to defend themselves against oxidative stress, a finding that could shift how we understand age-associated conditions such as diabetes and neurodegenerative diseases.
UCLA study may help explain why certain liver tumors return after thermal ablation
A new study led by investigators at the UCLA Health Jonsson Comprehensive Cancer Center may help explain why certain liver tumors return quickly after thermal ablation, a widely used minimally-invasive, image-guided technique that kills cancer cells by applying intense heat through a needle-like probe.