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Emerging adults with an average age of 19 who experienced four or more adverse childhood experiences had substantially higher rates of depression, suicidal ideation, hard drug use, and interpersonal violence than those who reported no childhood adversity.

Mount Sinai researchers have identified how APOE4, the strongest genetic risk factor for Alzheimer's disease, damages the brain's blood vessels and promotes the buildup of abnormal proteins linked to neurodegenerative disease.

Retrospective analysis of more than 20,000 patient records identifies opportunities for risk-mitigating approaches in certain patient populations.

Weill Cornell Medicine investigators have determined the mechanism by which a molecule within cells can help tune the light sensitivity of the eyes.

The Kissick Family Foundation, in partnership with the Milken Institute Science Philanthropy's Accelerator for Research and Collaboration (SPARC), today announced five research teams selected to receive a total of $2.5 million through the third funding cycle of the Kissick Family Foundation Frontotemporal Dementia (FTD) Grant Program.

Chronic stress and perceived social support may play a role in how memory and thinking abilities change with age, according to a new study led by researchers at Wake Forest University School of Medicine.

A new analysis of nearly 150,000 food and beverage products launched in the United States over the past decade, found that products bearing health-related claims are not only not consistently healthier, they are sometimes less nutritious.

Most people's blood pressure falls by 10 to 20 per cent while they sleep, giving the heart and blood vessels a chance to recover. But for some people, that nighttime dip never happens.

Community gathering places are intended to facilitate exercise and social participation for all residents, irrespective of functional decline status.

The National Institute of Information and Communications Technology (NICT, President: OHNO Hideo, Ph.D.) has discovered molecular mechanism of synaptic facilitation, instantaneous strengthening of synaptic transmission, which may be physiological basis of instantaneous memory.

A study carried out by GIKAFIT group of the EHU-University of the Basque Country shows that more than 80% of the athletes identify the more explicit behaviors but not other, more normalized, forms of interaction.

From osteoarthritis to a splitting migraine, when you’re experiencing pain, exercise can seem like the last thing you want or think you should do. But according to new Adelaide University research it could be one of the most effective ways to help ease your symptoms.

Gliomas are a major cause of cancer-related deaths in younger adults.

Children prescribed GLP-1 medications for weight loss, prediabetes, or type 2 diabetes are at risk for nutritional deficiencies – diagnosed in nearly one in six patients (16.8%) within the first year – according to a new study published in the journal Childhood Obesity.

At age 16, Alexander “Avi” Davidson fell 35 feet from the top of a telephone pole, an accident that left him paralyzed from the waist down and led to the amputation of his left arm below the elbow.

A brief report reviews emerging GLP-1 receptor co-agonists that also target GIPR, GCGR, and other receptors, examining their metabolic benefits alongside known and predicted cardiac effects. The authors highlight substantial species differences, warning that mouse heart studies may fail to predict responses in human cardiac tissue and that many proposed cardiac effects still require direct testing.

Researchers reviewed evidence linking GLP-1 and GLP-1 receptor agonists to chronic pain modulation through gut microbial, neuroimmune, vagal, and metabolic pathways, with the strongest clinical evidence currently involving knee osteoarthritis and idiopathic intracranial hypertension headache. Much of the proposed biology remains supported by preclinical research, and human studies have yet to establish that GLP-1RA-induced changes in the gut microbiome directly cause pain relief.

A review in Cell Reports Medicine examines how advances in oligonucleotide chemistry and delivery have established ASOs and RNA interference therapies as a class of genetic medicines, with 21 oligonucleotides approved at the time of writing. It also identifies extrahepatic delivery, safety, target validation, individualized treatment, and data quality as priorities as the field expands into common diseases and explores AI-assisted development.

Researchers analyzing paired gut microbiome samples from 125 Irish infants found that complementary feeding was associated with early changes in microbial composition and metabolic potential, including an increased capacity for complex carbohydrate metabolism. Breastfeeding duration was more closely associated with microbial community development than the timing of solid-food introduction, while formula-fed infants showed more extensive functional pathway changes after solids were introduced.

Emily Pfender, assistant professor in the department of communications at the University of Delaware, is a researcher on a new study in Health Communication.