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Researchers have identified a biological marker that rises and falls as body fat changes, offering new insight into how weight gain and weight loss may influence metabolic health.

A UK Biobank analysis of 66,483 adults found that longer daily moderate-to-vigorous activity bouts and less fragmented activity were associated with lower subsequent risks of inpatient diagnoses of dementia, depression, and anxiety, independent of total activity time. In neuroimaging data from 13,108 participants, these activity patterns were also associated with more favorable brain measures, although the observational analyses cannot establish cause and effect.

This narrative review found that non-nutritive artificial sweeteners have compound-specific and context-dependent associations with gut microbiota, metabolism, and health-related outcomes. Evidence does not support treating all sweeteners as uniformly harmful or safe, with human findings often limited or inconsistent.

Researchers used a UK survey and genetic data to examine whether higher neuroticism is associated with lower exercise engagement. Under the study’s Mendelian randomization assumptions, higher neuroticism was estimated to reduce participation in moderate and vigorous physical activity, while conscientiousness may lessen this effect.

Congenital heart disease is the most common birth defect, affecting approximately 1 in 100 babies born each year. One of the many causes for this disorder is having only one functional copy of the gene TBX5, instead of two healthy copies, inherited from parents.

Researchers from Carnegie Mellon University's School of Computer Science, the University of Pittsburgh School of Medicine and the University of Washington shed new light on Alzheimer's disease that could point to new directions for treatment.

Researchers have discovered that the human brain undergoes widespread age-related changes in genome regulation beginning in midlife that may help explain why aging is the greatest risk factor for neurodegenerative diseases such as Alzheimer's.

A major pillar of cancer immunotherapy involves stimulating T cells, the specialized killers of the immune system, to attack tumors.

Disrupted sleep and anxiety may be an ongoing issue for many people after the pandemic, whether due to COVID-19 directly or to the stress and anxiety caused by the global pandemic, and may contribute to the fatigue commonly reported by people with Post-COVID-19 Syndrome (PCS, or 'long COVID').

Cardiovascular risk factors are linked to higher risk of heart disease, but it has been unknown how they are related to abrupt closure of the coronary arteries leading to heart attack and sudden cardiac death.

Nearly half of childhood tumors treated with common types of chemotherapy showed detectable DNA changes linked to treatment within 18 months, according to a new international study led by The Hospital for Sick Children (SickKids).

New research has shown that RNA-based testing can improve the detection and interpretation of clinically actionable genomic alterations leading to MET exon 14 skipping in lung cancer patients—important biomarkers that may be missed by DNA-only approaches.

For decades, selenium has been recognized as an essential micronutrient, and glutathione peroxidase 4 (GPX4)-a selenium-containing enzyme-has been widely regarded as the central guardian against ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation.

A dream holiday, an exotic destination, a long-haul flight, and finally some well-deserved rest. The problem is that many travelers arrive at their destination only to spend the first days of their vacation struggling with fatigue, sleep disturbances, low energy levels, and digestive issues.

Scientists at The Wistar Institute have identified a new mechanism behind the chemotherapy resistance that makes ovarian cancer so lethal.

Lifestyle modification is the cornerstone of managing metabolic dysfunction-associated steatotic liver disease (MASLD), a growing cause of chronic liver disease worldwide.

Epilepsy affects over 50 million people worldwide, making it one of the most common neurological disorders.

A patient with a severe infection is prescribed a potent antibiotic. Hopes for improvement are high, but just after treatment is given, resistance to the drug increases thousands of times. How could this happen?

For patients diagnosed with cancer, continuing to smoke during treatment may shorten survival.

Antimicrobial resistance is one of the world's most alarming public health challenges, because the multidrug-resistant (MDR) gram-negative bacteria increasingly render even last-line antibiotics ineffective, leading to substantially higher mortality rates.