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We all know the feeling: the mental clarity that comes after a good run or a heavy workout. Science backs this up, even showing that for non-severe depression, exercise can be just as effective as antidepressants or therapy.

An individualized neoantigen mRNA vaccine was tested in patients with early-stage triple-negative breast cancer and showed feasibility, safety, and strong T cell immune responses. Long-term follow-up suggested durable immune memory with encouraging relapse-free outcomes, though controlled trials are needed to confirm clinical benefit.

A new electronic implant system can help lab‑grown pancreatic cells mature and function properly, potentially providing a basis for novel, cell-based therapies for diabetes.

A large, multi-center study recently published online in the Journal of the National Comprehensive Cancer Network (JNCCN) provides new insight into the long-term health effects of contemporary chemotherapy regimens used to treat testicular cancer, highlighting differences in renal function, cardiovascular risk, and the overall burden of chronic health conditions among survivors.

Can fragments of tumor DNA in the blood predict whether chemotherapy will be effective? Researchers at the Princess Máxima Center investigated this question together with experts from Italy and Slovakia.

Babies with an increased likelihood of autism may struggle to settle into deep, restorative sleep, according to a new study from the University of East Anglia.

This review examines how GLP-1 receptor agonists and the gut microbiome influence one another through bile acid signaling, short-chain fatty acids, and inflammatory pathways. It explores how microbial composition may shape treatment response and highlights the need for controlled human studies to enable microbiome-informed precision therapy.

Researchers used 16S rRNA sequencing and machine learning to identify gut microbiome patterns associated with insulin resistance severity in people with type 2 diabetes. XGBoost models showed that specific bacterial genera, including Bacteroides and Faecalibacterium, help distinguish individuals with higher insulin resistance from healthy controls.

Researchers developed DeepRare, an LLM-driven multi-agent diagnostic system that integrates clinical descriptions, phenotype data, and genomic information to improve rare disease identification. Across thousands of cases, the system showed higher diagnostic recall than existing AI tools and clinicians in benchmark testing, while providing traceable reasoning linked to medical evidence.

A study of over 50,000 pregnant women in Norway during the 2023/24 influenza season found that only 29.9% were vaccinated against influenza and 12.1% against COVID-19 during pregnancy, remaining far below recommended targets.

When you finish a run, your muscles may feel like they did all the work. But researchers at The Jackson Laboratory (JAX) and the University of Pennsylvania (UPenn) have discovered that what happens in your brain after a run may determine whether you gain endurance over time.

With careful selection, same-day hospital discharge was found to be feasible and safe in around one-fifth of patients undergoing transcatheter aortic valve implantation in a study presented today at the EAPCI Summit 2026.

Food insecurity can increase anxiety and undermine employees at work, but workplace programs to address it can improve job outcomes, according to research published by the American Psychological Association.

Exposure to infection and other immune stress in the womb increases the likelihood of alcohol misuse in adulthood, a risk that may be reduced through prenatal antioxidant treatment, a new Washington State University study shows.

Doctors usually focus on a person's average blood pressure, but research increasingly shows that how much blood pressure fluctuates from moment to moment is just as important.

The urgent onset of "the munchies" after cannabis use isn't imaginary – it's a cognitive response that occurs regardless of sex, age, weight or recent food consumption and could offer clues to help people struggling with appetite loss.

New medical developments make it possible to treat an increasing number of severe and rare diseases with novel, high-cost pharmaceuticals.

A new study led by Marie-Pierre Sylvestre, professor at the Université de Montréal School of Public Health, examines cannabis use 4 to 5 years after Canadian legalization by adopting a different perspective: rather than focusing solely on at-risk cases or those associated with problems, it identifies the socio-demographic, mental health, and lifestyle profiles of those who present a low risk of cannabis use disorder (CUD).

Certain neighborhood characteristics, including higher poverty, more uninsured residents, and lower educational attainment, may lead to an increase in COPD-related emergency department visits and hospitalizations, according to a new study in the January 2026 issue of Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation, a peer-reviewed, open access journal.

Scientists at Nagoya University in Japan have found two gut bacteria working together that contribute to chronic constipation.