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Oral semaglutide delivered meaningful reductions in HbA1c and body weight among GLP-1RA-naïve adults with type 2 diabetes in a Dutch real-world cohort. Lipid levels and blood pressure showed only small changes, reflecting modest cardiometabolic effects outside glucose and weight control.

Bladder cancer ranks among the ten most common types of cancer worldwide. The main treatment is bladder removal surgery, and despite advances in systemic therapies, recurrence is frequent in the most aggressive forms of the disease.

UCLA research finds that fewer than 1 in 4 eligible younger adults completed colorectal cancer screenings after the United States Preventive Services Task Force (USPSTF) lowered the recommended screening age to 45 from 50.

Polycystic kidney disease (PKD) is a debilitating hereditary condition in which fluid-filled sacs form and proliferate in the kidneys. Over time, the painful, growing cysts rob the organs of their function, often leading to dialysis in advanced cases.

Replacing beef with a plant based beef substitute for six days changed the fatty acid composition of human milk, increasing medium chain saturated fats and lowering key long chain polyunsaturated fats such as arachidonic acid. These biochemical shifts occurred without changes in maternal weight, appetite, glucose patterns or infant milk intake.

Obesity severity is incrementally associated with a broad range of cardiometabolic and renal disease burden, as discovered by researchers at Pennington Biomedical Research Center. Recently published in Obesity, the paper "Association of Obesity Severity with Cardiometabolic and Renal Disease Burden in the United States," explored the relationship through a cross-sectional study of data from the U.S. Behavioral Risk Factor Surveillance System survey.

A study published in the Journal of Critical Care, conducted with the participation of the D'Or Institute for Research and Education (IDOR), investigated how to measure efficiency in the use of resources for patients with severe community-acquired pneumonia (CAP), an illness contracted outside hospital settings and most common among older adults.

Researchers implanted electrodes in the human nucleus accumbens to track brain activity during severe food preoccupation in an individual taking tirzepatide. They found that a delta–theta biomarker disappeared during symptom-free periods and re-emerged weeks before relapse, suggesting a possible neural marker of vulnerability to dysregulated eating.

The review synthesizes evidence on whether Alzheimer’s disease medications can improve neurocognitive outcomes in children and adolescents with autism and low IQ. Across 12 studies, preliminary findings show promising gains in language, executive function, learning and memory, and general cognitive ability, particularly in younger children.

An analysis of data from almost two dozen long-term studies finds that even low-intensity smokers have a substantially higher risk of heart disease and death compared to people who never smoked, even years after they quit.

Growing from a single cell into a complex organism with specialized tissues and organs requires a complex and coordinated process.

Researchers at the University of California San Diego School of Medicine have identified a promising new therapy for triple-negative breast cancer (TNBC), which is among the most aggressive and difficult-to-treat forms of the disease.

Postmenopausal osteoporosis is a condition that weakens bones, making them brittle and prone to fracture.

A combination blood stem cell and pancreatic islet cell transplant from an immunologically mismatched donor completely prevented or cured Type 1 diabetes in mice in a study by Stanford Medicine researchers.

Vaccination rates are falling in many communities due to widespread misinformation and previously eliminated or controlled illnesses like measles are surging across the United States and Canada.

Artificial intelligence has exploded in popularity in recent years, and many proponents are excited about its potential uses in medicine: for example, processing samples quickly or identifying markers of disease that may be missed by the human eye.

Aggressive cancer cells are masters of movement. When they spread through the body, they cause metastasis, which significantly reduces a person's chance of survival.

New research from Mass General Brigham finds that adolescents and young adults who stayed on the medication buprenorphine for at least a year had markedly lower risks of opioid overdose and hospitalization compared with peers who discontinued medication early or took it inconsistently.

Gestational diabetes can cause a multitude of complications in the offspring, but to date, the reasons are incompletely understood.

A new study investigating neuroinflammation in the ventral tegmental area (VTA) of the brain, a small, midbrain dopaminergic region, has found that acute and chronic depression are associated with distinct pathophysiological mechanisms.