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Oral health function linked to markers of lifestyle-related diseases in older adults
The term 'oral health' refers to the health of the mouth, teeth, gums, and other related structures, and it is closely linked with our well-being and quality of life.
Pathogenic mechanisms of Fusobacterium nucleatum in colorectal cancer and emerging therapies
In recent years, the regulatory role of the gut microbiota in the initiation and progression of colorectal cancer (CRC) has attracted growing attention. Among the key microbial contributors, Fusobacterium nucleatum (Fn) has been identified as a critical pathogenic factor in CRC.
Social media analysis reveals emotional burden of children with multiple health conditions
Children with multiple long-term health issues undergo severe emotional stress at the same time as they are trying to cope with the physical challenges of their condition, a study has found.
Therapeutic potential of houttuynia cordata polysaccharide in H1N1 and MRSA-induced acute pneumonia
This new article publication from Acta Pharmaceutica Sinica B, discusses how an anti-complement homogeneous polysaccharide from Houttuynia cordata ameliorates acute pneumonia with H1N1 and MRSA coinfection through rectifying Treg/Th17 imbalance in the gut–lung axis and NLRP3 inflammasome activation.
ALKBH3 regulates glycolysis and doxorubicin resistance in triple negative breast cancer
This new article publication from Acta Pharmaceutica Sinica B, discusses how ALKBH3-regulated m1A of ALDOA potentiates glycolysis and doxorubicin resistance of triple negative breast cancer cells.
Stereotactic radiation shows promise for small cell lung cancer with brain metastases
A new study led by investigators from Mass General Brigham trialed stereotactic (targeted) brain-directed radiation in 100 patients with small cell lung cancer and brain metastases, finding they experienced positive outcomes that support use of targeted radiation in the future for such patients.
Melatonin receptor signaling counters sleep fragmentation-mediated infertility in T2DM
This new article publication from Acta Pharmaceutica Sinica B, discusses how melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1.
CMD-OPT model enables discovery of potent and selective RIPK2 inhibitor for acute liver injury
This new article publication from Acta Pharmaceutica Sinica B, discusses how a CMD-OPT model enables the discovery of a potent and selective RIPK2 inhibitor as preclinical candidate for the treatment of acute liver injury.
Prefrontal cortex RNA drives female-specific brain resilience to depression
A traditionally overlooked type of RNA plays an important role in promoting resilience to depression-but only in females.
Exploring the roles of orphan nuclear receptors in MASLD pathogenesis
Metabolic dysfunction-associated steatotic liver disease (MASLD), affecting approximately 30% of the global population, represents a spectrum of liver disorders ranging from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, and cirrhosis.
Blastocystis infection found in nearly one in four schoolchildren in northeastern Gabon
Announcing a new article publication for Zoonoses journal. This study was aimed at assessing the prevalence of infection with Blastocystis, an intestinal protozoan parasite, among school-aged children, and to identify associated risk factors.
Study shines new light on how harmful industries shape scientific narratives
A new study, published in Addiction, shines a light on how industries associated with health harms-such as tobacco, fossil fuels, and in this case, alcohol-can distort the evaluation of scientific research through industry-friendly commentary.
Global project measures true cost of healthy diets
A decade-long project measuring access to healthy foods worldwide is wrapping up in August, after shedding new light on the scope and specifics of nutrition insecurity, kickstarting solutions, and shifting the conversation around the affordability of healthy diets.
Osteoblast estrogen receptor signaling found essential for bone integrity
Estrogen plays an important role in keeping bones healthy. Now, researchers investigated how membrane-initiated estrogen receptor alpha (mERα) signaling in specific cell types of female mice affects bone health.
Hepatitis C treatment gaps persist for children and new mothers
As the opioid epidemic has worsened in the United States, prevalence of hepatitis C has also increased. Hepatitis C is a bloodborne virus that damages the liver.
Brain protein associated with aging not linked to youth contact sports
In recent years, some scientists and advocates have warned that playing contact sports like football and hockey may increase the risk of brain diseases like Alzheimer's disease or chronic traumatic encephalopathy (CTE) due to a buildup of a specific protein in the brain.
New analysis reveals widespread progression of CKM syndrome across the U.S.
One in three adults in the U.S. has three or more risk factors for a newly recognized but increasingly common condition: cardiovascular-kidney-metabolic (CKM) syndrome.
Maternal depression found to disrupt key parenting behaviors
Mothers experiencing depression have considerable challenges across multiple parenting domains, according to a global systematic review published in the July issue of Harvard Review of Psychiatry, part of the Lippincott portfolio from Wolters Kluwer.
Scientists identify key role of T-bet in flu memory B cells
At the surface, the immune response to a flu virus is simple. Some cells recognize the pathogen and send a signal to the immune system, and immune cells produce a potentially lifesaving antibody against the virus. Antigen in, antibody out.
Autistic adults describe mental strain of nonverbal communication
Imagine having a conversation where every gesture and glance feels like a test. You're juggling eye contact, facial expressions, and tone of voice, all while trying to keep up with the words. You might miss something, or someone might misread you.