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Researchers mapped immune cells from centenarians, their offspring, and younger controls across three cohorts using multi-omics single-cell profiling. They found that centenarians retain leaner helper pools but have enhanced cytotoxic and NK cell programs, along with reinforced NK–T communication networks.

Southwest Research Institute (SwRI) and The University of Texas at San Antonio (UT San Antonio) are advancing a smart biosensor coating to streamline the production of immunotherapies for cancer treatments.

Mustafa Sahin, MD, PhD, Neurologist-in-Chief and Chair of the Department of Neurology at Boston Children's Hospital, and his collaborators have been awarded an NIH grant of over $8.6 million for the third five-year cycle of the Rare Disease Clinical Research Network (RDCRN) project, "Developmental Synaptopathies Associated with TSC, PTEN, SHANK3, and SynGAP1 Pathogenic Variants".

A new Mayo Clinic study finds that many heart attacks in people under 65 - especially women - are caused by factors other than clogged arteries, challenging long-standing assumptions about how heart attacks occur in younger populations.

A pioneering international project led by prominent female scientists, involving research staff from the Universidad Carlos III de Madrid (UC3M) and promoted by the Spanish Space Agency (AEE), has just completed its parabolic flight campaign in Bordeaux (France).

People living in the UK and following a diet close to the Mediterranean diet are more likely to have better gum health, with potentially lower amounts of gum disease and inflammation.

A specialist form of therapy could offer hope for some of the most vulnerable young PTSD sufferers – according to a University of East Anglia study.

Patients who have a new type of lens implanted in their eyes during surgery for cataracts or to correct their eyesight have excellent or good vision over distances both near and far, and often no longer need spectacles for reading.

A new synthesis of global evidence finds that experiencing gestational diabetes during pregnancy is linked with a decline in intellectual function among mothers, and may increase the risk of neurodevelopmental disorders, including autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD) in children.

The relative increase in odds of an individual with diabetes developing severe symptoms of depression – and vice versa – is the same, regardless of where they live, a study of over-50s in 18 countries in Europe that is being presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15-19 September) has found.

In women with type 2 diabetes (T2D), use of hormone replacement therapy (HRT) skin patches is not associated with a higher risk of blood clots or stroke.

It is possible to be "fat but fit", new research being presented at the annual meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15-19 September) suggests.

Cannabis use is linked to an almost quadrupling in the risk of developing diabetes, according to an analysis of real-world data from over 4 million adults, being presented at this year's Annual Meeting of The European Association for the Study of Diabetes (EASD) in Vienna, Austria (15-19 Sept).

Dry eyes can cause significant discomfort, and the symptoms become more common as we age. However, until now, it was unclear what proportion of the population suffered from the condition, with estimates ranging from 5-50%.

Everybody develops presbyopia as they age – a difficulty in focusing on near objects and text – and often have to resort to reading glasses. However, the solution might be as simple as using special eye drops two or three times a day.

Beckman Coulter Life Sciences, a Danaher company and a global leader in laboratory automation and innovation, announces the launch of its new IR820 and IR870 infrared dye antibody conjugates.

The new class of anti-obesity drugs, glucagon-like peptide-1 receptor agonists (GLP-1RAs), is proving remarkably effective at helping individuals lose weight.

A large, real-world randomized trial in Denmark found that the RSVpreF vaccine reduced RSV-related hospitalizations in adults aged 60 and over by over 80%. The vaccine also showed protection against broader respiratory illness with a favorable safety profile.

Researchers used drug-target Mendelian randomization to test whether genetically proxied activation of GLP1R and GIPR influences alcohol-related behaviors. They found that GIPR, especially when combined with GLP1R, was linked to lower binge and heavy drinking, healthier food preferences, improved liver markers, and reduced coronary artery disease risk.

Researchers analysed mortality data from 185 countries and found that while global non-communicable disease (NCD) deaths before age 80 declined from 2010 to 2019, progress slowed compared to 2001–2010. Gains were mainly from drops in heart disease and stroke, but rising burdens from diabetes, cancers, and neuropsychiatric conditions stalled momentum.