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Efforts to promote safer opioid prescribing in Canada appear to be having an effect, as new research in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.250670 shows a decrease in opioid dispensing between 2018 and 2022.

ALS, also known as Lou Gehrig's disease, is among the most challenging neurological disorders: relentlessly progressive, universally fatal, and without a cure even after more than a century and a half of research.

A team led by the UAB Institut de Neurociències (INc-UAB) has for the first time identified the mechanism behind a potentially fatal type of epilepsy, a symptom of mitochondrial diseases.

Lawsonia inermis is best known for making henna, a versatile dye that is used to change the color of skin and clothes. Now, researchers from Osaka Metropolitan University have found another use for the pigments extracted from the dye: treating liver disease.

Is expanding hospital inpatient, or bed-based, care a way to help address the overdose crisis? An analysis article in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.240955 describes the RE-AIM framework (Reach, Effectiveness, Adoption, Implementation, and Maintenance), which can help provinces determine whether bed-cased care is effective.

Rhabdomyosarcoma (RMS) accounts for up to 10% of childhood cancers and nearly half of pediatric soft tissue sarcomas.

Physical fitness, physical activity and screen time are associated with brain mechanisms underlying mental health and learning, according to two recent studies from the University of Eastern Finland and Kuopio University Hospital.

Treating chronic neuropathic pain with spinal cord stimulation may help prevent excess mortality associated with chronic pain, a new study from the University of Eastern Finland and Kuopio University Hospital shows.

A large U.S. survey found that most adults and children frequently engage in outdoor activities that expose them to ticks, yet only a minority consistently use protective measures. Despite widespread awareness of Lyme disease, prevention behaviors remain inconsistent, especially during routine yard time.

A large UK Biobank study found that higher night-time light exposure is linked to significantly greater risks of coronary artery disease, stroke, heart failure, and other cardiovascular conditions. The findings suggest maintaining darker nights and adequate daytime light could support heart health.

A BMJ study found that individuals exposed to sugar rationing during their first 1,000 days of life had significantly lower risks of heart attack, stroke, and heart failure in adulthood. Early-life sugar restriction was linked to a 2.5-year delay in cardiovascular disease onset, suggesting long-term benefits for heart health.

Semaglutide lowered the risk of major adverse cardiovascular events across all body weight and waist circumference levels in people with overweight or obesity and cardiovascular disease. Early waist reduction explained only a third of this benefit, showing that semaglutide’s heart protection extends beyond fat loss.

A population-based study of over two million births in Ontario found that prenatal exposure to the sulfate and ammonium components of fine particulate matter (PM₂.₅) was associated with a higher risk of autism spectrum disorder. The risk was greatest during mid to late pregnancy and among infants in urban, lower-income neighborhoods.

A new review challenges assumptions about ultra-processed foods, finding that plant-based versions, such as soymilk, meat analogs, and soft margarines, may lower cholesterol and disease risk compared with unprocessed animal foods when used as replacements.

Scientists from the Institut Pasteur have genetically analyzed the remains of former soldiers who retreated from Russia in 1812.

Researchers at North Carolina State University have shown a link between the size of cockroach home infestations and the levels of both allergens and endotoxins in those homes, with lowering roach infestation numbers through pest control triggering significant declines in the levels of allergens and endotoxins.

Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system.

A comprehensive analysis of over 5.2 million hospitalizations reveals a troubling surge in severe diverticulitis cases among Americans younger than 50.

Winter vomiting disease is caused by the Norovirus, which is most virulent during the colder half of the year.

The tiny blood vessels in your eyes might hold the key to predicting a person's risk of developing heart disease and how fast they're biologically aging, according to researchers at McMaster University and Population Health Research Institute (PHRI) - a joint institute of Hamilton Health Sciences and McMaster.