Feed aggregator

Mechanosensitive Piezo ion channels, particularly Piezo1 and Piezo2, are gaining recognition as central regulators of digestive system physiology and disease.

Wildfires are well-known health risks. Now, in a new Frontiers in Environmental Health study, researchers in the US have – for the first time – evaluated how prenatal PM2.5 exposure has changed over space and time on a national scale, and what role wildfires play in shaping these trends.

A growing understanding of purinergic signaling is reshaping how scientists view osteoarthritis (OA), revealing an intricate communication network that influences joint inflammation, cartilage degeneration, bone remodeling, and chronic pain.

A comprehensive new review examines the complex role of T cell exhaustion in organ transplantation, highlighting how this dysfunctional immune state can both promote graft tolerance and create vulnerabilities to infection and malignancy.

A major new Adelaide University research program will strive to improve the lives of millions by developing targeted therapies for chronic visceral pain, a debilitating primary symptom associated with irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) and endometriosis.

Being single can be a unique and meaningful opportunity for personal growth, according to new research in Personality and Social Psychology Bulletin.

A nationwide case-control study of older U.S. Medicare beneficiaries found that living closer to a dry-cleaning establishment was associated with higher odds of incident Parkinson’s disease, with the strongest association among people living within 0.1 mile.

Investigators at Dana-Farber Cancer Institute have developed a platform for systematically discovering molecular glues that could become protein degradation drug candidates.

A growing understanding of RNA biology is reshaping how scientists view the relationship between environmental toxicants, brain development, and neurodegenerative disease.

Knee osteoarthritis (KOA) affects more than 1 in 10 people over 40 years of age, impairing patients' mobility and quality of life.

Higher ambient PM2.5 exposure was associated with increased rheumatoid arthritis disease activity and a greater likelihood of flares in a four-year South Korean cohort of 1,070 patients. The association appeared stronger with sustained exposure over approximately two weeks or longer, while women and nonsmokers showed more pronounced links between PM2.5 and DAS28-CRP.

A low-fat vegan diet lowers the energy density of the foods people eat by roughly 30%, allowing them to eat satisfying amounts of food while taking in fewer calories and losing weight-without deliberately restricting calories-according to new research published in JAMA Network Open.

A growing understanding of trained immunity, a form of long-lasting immune system adaptation, is reshaping how scientists view diabetes and its many complications.

Fruit, honey and other naturally sweet foods may have helped fuel the evolution of the human brain, according to new research from the University of Sydney and the University of Glasgow.

Mega-scale exome sequencing of 1,032,116 people identified 59 independent genes linked to the TG:HDL ratio, including 44 rare-coding associations not detected in the previous largest analysis. Ultra-rare FNIP1 loss-of-function variants were associated with favorable fat distribution, lower liver fat and glycemia, and around 60% lower odds of a composite cardiometabolic disease outcome.

A longitudinal study of 1,154 hospitalized COVID-19 patients found widespread reactivation of chronic Herpesviridae and Anelloviridae, with distinct viral patterns linked to disease severity, inflammation, and clinical outcomes. Anelloviridae also persisted during convalescence and were associated with physical deficits in long COVID, although the study did not establish causation.

A population-based study of 26,582 live singleton births in Madrid found that associations between NO₂ exposure and adverse birth outcomes varied by pregnancy stage, with key patterns emerging in the first and third trimesters.

A randomized trial found that 2 mg nicotine gum controlled craving, anxiety, and sleep problems more effectively than behavioral counselling during smokeless tobacco cessation. Although abstinence rates were numerically higher with nicotine gum, the differences were not statistically significant, highlighting the need for larger studies.

Drug resistance remains one of the greatest obstacles to successful treatment of gastric cancer, limiting the long-term effectiveness of the widely used chemotherapy drug cisplatin.

Researchers from Keio University have found that D-serine increases the growth of gastric cancer by creating an immunosuppressive and anti-inflammatory tumor microenvironment.