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A long-term study of 12,409 adults found that a greater burden of diabetes, hypertension, and current smoking in midlife was associated with substantially fewer years lived free of dementia. Adults with none of these risk factors had about 30.1 dementia-free years from age 55, compared with 17.5 years among those with all three, a difference of nearly 13 years.

A single 25-mg dose of psilocybin with psychological support was feasible to deliver within an NHS setting and produced large preliminary reductions in depressive symptoms among adults with treatment-resistant depression. The Phase 2 feasibility trial also found the treatment was generally well tolerated, although functional unblinding and expectancy effects mean larger, longer efficacy studies are needed.

Researchers created T2T-HG002, a near-perfect diploid human genome benchmark that is free of detectable errors across 99.4% of the genome and captures both maternal and paternal haplotypes. The benchmark expands coverage into previously excluded genomic regions and provides a new framework for evaluating sequencing reads, assemblies, phased variants, and personalized genome inference.

A study of 4,818 middle-aged and older Chinese adults found that higher light BioAge was associated with greater risks of cognitive impairment, episodic memory decline, and reduced mental intactness. The simple measure, based on age, creatinine, glucose, and CRP, added modest predictive information but requires further validation before clinical use.

A narrative review finds that pulses may support gut and metabolic health through their fiber, protein, phytochemicals, and interactions with the gut microbiota, while offering a lower environmental footprint than many animal protein sources. Human evidence is strongest for selected cardiometabolic outcomes, while many microbiome and fermentation-related benefits remain supported mainly by animal and laboratory studies.

A nationwide geospatial analysis of 151,366 publicly accessible parks found that 52.6% lay within two miles of at least one industrial facility reporting toxic chemical management to the EPA, while 17.7% had parkland within two miles of a current or former Superfund site. The study mapped proximity rather than contamination or exposure, highlighting locations where targeted environmental assessment and healthier urban planning may be warranted.

While Black and Hispanic families are enthusiastic about research participation, other provider- and systems-focused factors may influence their involvement in pediatric oncology clinical trials, a UT Southwestern Medical Center-led study has found.

Immune checkpoint inhibitors, cancer vaccines and cellular therapies have reshaped oncology, yet most patients still do not achieve lasting benefit.

Understanding how heart muscle cells stop dividing and acquire the characteristics needed to sustain lifelong cardiac function remains one of the greatest challenges in cardiovascular biology.

Women live longer than men in nearly every country in the world, yet they experience higher rates of disability, dementia and many other age-related conditions.

The prefrontal cortex, a brain region long associated with learning more flexible behaviors, can sometimes block the ability to think outside the box, a new study in mice shows.

Researchers at Duke University School of Medicine are investigating how to keep opioids' pain-relieving benefits while reducing their addictive potential. In a study published in Nature, they report a step toward that goal.

Malaria kills more than half a million people a year, most of them young children in Africa. Two vaccines are now recommended by the World Health Organization, RTS,S and R21.

Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease in which the body's own immune system overreacts to minimal or inappropriate stimuli, producing recurrent attacks of fever and painful inflammation.

Like spies evading detection through being masters of disguise, many cancer cells are adorned with a copious coat of sugar-derived molecules that throws the proverbial hounds of our immune systems off the scent.

Why do some breast cancer patients face a much higher risk of distant metastasis, while others with seemingly similar disease experience far better outcomes?

The aberrant activation of the mTOR pathway and its crosstalk with other signaling cascades represent key drivers of hepatocellular carcinoma (HCC) progression. mTOR-mediated ferroptosis suppression has been implicated in HCC resistance to chemotherapy.

There is no such thing as a universal mosquito magnet. In a new study published in iScience, Florida International University (FIU) researchers pitted 119 human volunteers against three of the world's most dangerous mosquito species and found that not one person was attractive to all three.

Growth impairment is a common late effect of childhood stem cell transplantation. A Japan-wide study found that growth hormone therapy improves adult height, but prior radiation therapy and transplant-related complications negatively affect how much children benefit.

A study published in Nature Cell Biology reports a new vulnerability in acute myeloid leukemia (AML) that might lead to novel therapies to treat this cancer while minimizing harm to normal cells.