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Sexual violence against children and intimate partner violence against women are two of the most devastating yet persistently underrecognized global health challenges and rank among the top risks for mortality and morbidity worldwide, according to research published in The Lancet today.

A new report warns Deaf women experiencing domestic abuse in Scotland remain "effectively invisible" due to the chronic absence of specialist services and a lack of coordinated national support.

Researchers identified trimethylamine (TMA) as a gut microbe–derived metabolite that directly inhibits IRAK4 to reduce metabolic inflammation and improve glycaemic control in high-fat-diet-fed mice. Choline-driven increases in TMA production replicated these benefits, revealing a host–microbe signaling axis with therapeutic potential for obesity-associated insulin resistance.

Mpox virus clade Ib shows a longer and more variable incubation period than previously characterized clades, with symptom onset extending well beyond 21 days in a substantial minority of cases. Incubation varies by transmission route, with shorter intervals after sexual exposure and longer periods following nonsexual community transmission, raising implications for surveillance and postexposure guidance.

A large volcanic eruption or cluster of eruptions in the mid-1340s triggered severe climate anomalies that drove harvest failures across parts of Europe. These shocks reshaped Mediterranean grain trade routes, likely introducing plague-infected fleas into Italian ports and helping ignite the Black Death.

With cannabis-related vehicle crashes on the rise, a new study suggests that prevention campaigns shouldn't focus just on young people.

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a small molecule that can inhibit a cancer-driving protein long considered impossible to target with drugs - a discovery that could open the door to a new class of treatments for leukemia and other hard-to-treat cancers.

A new national study shows for the first time that people exposed to Agent Orange face a higher risk of developing myelodysplastic syndrome (MDS), tend to develop it earlier, and often have more aggressive disease that is more likely to progress to acute myeloid leukemia.

Washington State University researchers have discovered how a neural circuit – or a connection between two brain regions – drives relapse after opioid use, a finding that could lead to more effective treatments for opioid use disorders.

The negative health impacts from contamination by so called "forever chemicals" in drinking water costs the contiguous U.S. at least $8 billion a year in social costs, a University of Arizona-led study has found.

Preliminary results of a nationwide study suggest that the disinfectant used to treat water before it is distributed through pipes may impact the incidence of Legionnaire's disease in certain parts of the country.

McGill University researchers have identified a brain function that helps explain why childhood stress raises metabolic health risks for some women later in life.

In a major step towards a precision therapy for Clostridioides difficile (C. diff) infection, researchers at The Hospital for Sick Children (SickKids) have uncovered how the body's bile acids bind to block C. diff's most dangerous toxin.

Reducing calorie intake helps cancer-fighting immune cells do their jobs more effectively, reports a study by Van Andel Institute scientists and collaborators.

A first-of-its-kind University of Stirling-led study could lead to quicker and more targeted support for vulvodynia - a painful chronic condition estimated to affect more than one in 10 women with no known cause.

In a new preclinical study, researchers from The University of Texas MD Anderson Cancer Center developed an antibody therapy called 77A that showed an ability to overcome treatment resistance in blood cancers, such as myeloma and lymphoma, as well as solid tumors.

Australian researchers have for the first time pinpointed specific genetic changes that increase the risk of severe, sight-threatening forms of age-related macular degeneration (AMD).

A new study shows that in 2023, substance use disorders led to nearly $93 billion in lost productivity in the United States from missed work, reduced job performance, inability to work, and lost household productivity.

Researchers at Bielefeld University have analyzed how reliably AI methods can detect pulse rates from simple video recordings.

High BMI and poor physical fitness during later adolescence increase the risk of both contracting and dying from sepsis and other severe bacterial infections in adulthood, according to a study from the University of Gothenburg.