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A research team led by Albert Einstein College of Medicine scientists has developed a new strategy to engineer immune cells that dramatically prolongs their effectiveness after being infused into patients to fight cancer and HIV, addressing a major limitation of current treatments.

Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare.

Persons under stress may have a harder time spatially orienting themselves. Researchers in Bochum have discovered why.

Macrophages are central to mechanobiology research: their physical characteristics-stiffness, adhesion, and ECM (extracellular matrix) sensing-are inextricably linked to their phenotypic polarization and immune function.

A new, national analysis published in the Aesthetic Surgery Journal suggests the future growth of aesthetic surgery may lie far from traditional luxury markets.

A new research paper was published in Volume 18 of Aging-US on March 2, 2026, titled "D, L-Buthionine-(S, R)-sulfoximine recapitulates the anti-obesity effects of sulfur amino acid restriction without the associated deleterious effects on bone in male mice."

AI-powered toys that "talk" with young children should be more tightly regulated and carry new safety kitemarks, according to a report that warns they are not always developed with children's psychological safety in mind.

Advanced proteomics and AI reveal blood protein changes, offering insights into early Alzheimer's detection and differentiation from mild cognitive impairment.

Making a living brain transparent and watching its neurons fire without disturbing their function-sounds like science fiction, doesn't it? Yet the solution may already exist within our own bodies.

Cancer is caused by faulty genes, but what also shapes a cancer cell's behaviour is how a gene's instructions are trimmed and rearranged before they are turned into the proteins that keep a cell alive.

In type 1 diabetes, the immune system starts to destroy insulin-producing beta cells in the pancreas. Progressive loss of these cells destabilizes the body's glucose levels and drives the course of the disease, so preserving or restoring beta cell mass is a central treatment goal.

Scientists at the University of Cambridge have developed a new way to alter complex drug molecules using light rather than toxic chemicals – a discovery that could accelerate and improve how medicines are designed and made.

Researchers analyzed molecular sensitization patterns in Polish patients with perennial allergic rhinitis who tested positive for cockroach allergens. They found that most apparent cockroach allergies were driven by cross-reactive proteins shared with mites, seafood, and other arthropods rather than true cockroach-specific allergens.

Immunotherapy given during and after chemoradiation did not improve survival for study participants with limited-stage, small-cell lung cancer (SCLC) according to the results of an international clinical trial, NRG-LU005, led by NRG Oncology in collaboration with the Alliance for Clinical Trials in Oncology. The results are published in the Journal of Clinical Oncology.

Biologists at the National University of Singapore (NUS) have uncovered how the protein NuSAP safeguards tiny structures inside cells called centrioles, revealing a mechanism linked to developmental disorders such as microcephaly and mosaic variegated aneuploidy (MVA) syndrome.

A randomized crossover trial found that replacing red meat patties with processed plant-based meat alternatives for six days significantly lowered circulating trimethylamine N-oxide (TMAO), a gut-derived metabolite linked to cardiovascular risk. The plant-based phase also produced modest reductions in cholesterol markers but slightly increased weight and NT-proBNP, possibly due to higher sodium intake.

Scientists tracking the entire life of the African turquoise killifish have discovered that behavior alone can predict whether an animal will live a long or short life.

Researchers identified in mice a microbiome–gut–brain pathway in which age-associated changes in gut microbes increase medium-chain fatty acids that impair vagal sensory signaling and hippocampal activity. These interoceptive disruptions weaken memory formation, revealing a microbial mechanism that contributes to cognitive decline during aging.

A team of researchers at the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC has identified important differences in how early Alzheimer's disease-related brain changes appear across racial and ethnic groups, underscoring the need for more inclusive approaches to studying and diagnosing the disease.

A new preclinical study in mice shows that precancerous cells in the pancreas can be eliminated before they have the chance to become tumors.